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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study aims to evaluate the acceptability, safety, and preliminary efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors (STB) among adults with recent and frequent suicide ideation.
The present study is a one-arm open trial designed to evaluate the safety, acceptability, and preliminary efficacy of Therapeutic Evaluative Conditioning for Suicide (TEC-S), a smartphone-delivered intervention aimed at reducing suicidal thoughts and behaviors (STB). Participants in this study will be 20 adult participants (ages 18+) who report recent and frequent STB, residing within the greater-Boston, MA area.
Participants will receive 3x/daily EMA and optional access to active TEC-S. Evaluative conditioning uses classical conditioning to alter attitudes. The aim of TEC-S is to alter attitudes toward suicide and, in turn, reduce STB. EMAs will monitor STB, safety, and acceptability, and efficacy. Weekly behavioral and self-report assays will assess hypothesized treatment mechanisms. The study's aim is to evaluate the safety, acceptability, and preliminary efficacy of Therapeutic Evaluative Conditioning for Suicide (TEC-S).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Smartphone-delivered active Therapeutic Evaluative Conditioning for Suicide (active TEC) | Experimental | Optional smartphone-delivered active Therapeutic Evaluative Conditioning for Suicide (active TEC-S) for 30 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S) | Behavioral | Therapeutic Evaluative Conditioning for Suicide (active TEC-S) is a behavioral treatment where participants are given optional access to a computerized task/game where they repeatedly pair suicidal behavior stimuli (pictures, words) with other negative stimuli and self-related stimuli with positive stimuli. |
| Measure | Description | Time Frame |
|---|---|---|
| TEC-S Acceptability | (i) Indexed as the proportion of TEC-S sessions accessed within the first week, (ii) adapted items from the Credibility/Expectancy Questionnaire (CEQ), rated on a 9-point scale. : "How satisfied were you with your overall experience with TEC-S?" "How satisfied were you with your understanding of how to complete TEC-S (iii)End-User Mobile Application Rating Scale (uMARS), with items rated on a 5-point scale. | Through completion of treatment phase (day 1 through 30) |
| TEC-S Safety | Changes in suicide-related thoughts (e.g., intent, desire, urge, preparation) and affective responses (e.g. stress) before and after randomized stimuli in each TEC-S session, assessed via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Measure | Description | Time Frame |
|---|---|---|
| Desire to die by suicide (Likert) | Right now, how strongly do you want to kill yourself? [0 (not at all) to 10 (extremely)](streamdown:incomplete-link) | Through completion of treatment phase (day 1 through 30) |
| Suicide urge (Likert) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adam C Jaroszewski, PhD | Contact | 781-258-3082 | ajaroszewski@mgh.harvard.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Boston | Massachusetts | 02114 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Jan 7, 2026 | Jun 29, 2026 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D013406 | Suicide, Attempted |
| D013405 | Suicide |
| ID | Term |
|---|---|
| D016728 | Self-Injurious Behavior |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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|
Right now, how strong is your urge to kill yourself [0 (not at all) to 10 (very strong)]; assessed via 3x/day ecological momentary assessment.
| Through completion of treatment phase (day 1 through 30) |
| Suicide thought incidence | Since the last survey, have you had suicidal thoughts? (yes/no); assessed daily via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicide preparation incidence | Since the last survey, have you made any preparations to kill yourself? (yes/no); assessed daily via ecological momentary assessment. | Through completion of treatment phase (day 1 through 30) |
| Suicide attempt incidence | Since the last survey, have you attempted to kill yourself? (yes/no); assessed daily via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicidal behaviors (composite) | A composite variable consisting of (i) suicide plan incidence, (ii) suicide preparation incidence, (iii) suicide attempt incidence, each assessed via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicidal aversion (AMP) | Suicide aversion assessed implicitly/behaviorally via the Affect Misattribution Procedure (AMP) | Through completion of treatment phase (day 1 through 30) |
| Suicidal aversion (Likert) | Valence ratings of suicide-related pictures using a 9-point scale (-4 [extremely unpleasant] to 0 [neutral] to 4 [extremely pleasant]); assessed weekly. | Through completion of treatment phase (day 1 through 30) |
| Suicidal affection (AMP) | Self affection assessed implicitly/behaviorally via the Affect Misattribution Procedure (AMP) | Through completion of treatment phase (day 1 through 30) |
| Suicide intent (Likert) | Right now, how strong is your intention to kill yourself today? [0 (I am definitely not going to kill myself today) to 10 (I am definitely going to kill myself today)]; assessed via 3x/day ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |