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| ID | Type | Description | Link |
|---|---|---|---|
| K23MH133876 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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This study aims to evaluate the acceptability, safety, and efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors (STB) among adults with recent and frequent suicide ideation.
The present study is a two-arm randomized controlled trial (RCT) designed to evaluate the safety, acceptability, and efficacy of Therapeutic Evaluative Conditioning for Suicide (TEC-S), a smartphone-delivered intervention aimed at reducing suicidal thoughts and behaviors (STB). Participants in this study will be 60 adult participants (ages 18+) who report recent and frequent STB, residing within the greater-Boston, Ma area.
Participants will be randomized to receive either the control condition, which consists of 3x/daily ecological momentary assessment (EMA) of emotions and STBs and optional inactive TEC (n = 30), or the experimental condition, consisting of 3x/daily EMA and optional active TEC-S (n = 30). Evaluative conditioning uses classical conditioning to alter attitudes. The aim of TEC-S is to alter attitudes toward suicide and, in turn, reduce STB. EMAs will monitor STB, safety, and acceptability, and efficacy. Weekly behavioral and self-report assays will assess hypothesized treatment mechanisms. The study's aim is to determine if the active TEC-S condition reduces STB and to explore if altered attitudes toward suicide mediates this effect.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Smartphone-delivered inactive Therapeutic Evaluative Conditioning (inactive TEC) | Placebo Comparator | Optional smartphone-delivered inactive Therapeutic Evaluative Conditioning (inactive TEC) for 30 days. |
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| Smartphone-delivered active Therapeutic Evaluative Conditioning for Suicide (active TEC) | Experimental | Optional smartphone-delivered active Therapeutic Evaluative Conditioning for Suicide (active TEC-S) for 30 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S) | Behavioral | Therapeutic Evaluative Conditioning for Suicide (active TEC-S) is a behavioral treatment where participants are given optional access to a computerized task/game where they repeatedly pair suicidal behavior stimuli (pictures, words) with other negative stimuli and self-related stimuli with positive stimuli. |
| Measure | Description | Time Frame |
|---|---|---|
| Desire to die by suicide (Likert) | Right now, how strongly do you want to kill yourself? [0 (not at all) to 10 (extremely)]; assessed via 3x/day ecological momentary assessment (Kleiman et al., 2018) | Through completion of treatment phase (day 1 through 30) |
| Measure | Description | Time Frame |
|---|---|---|
| Suicide intent (Likert) | Right now, how strong is your intention to kill yourself today? [0 (I am definitely not going to kill myself today) to 10 (I am definitely going to kill myself today)]; assessed via 3x/day ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adam C Jaroszewski, PhD | Contact | 781-258-3082 | ajaroszewski@mgh.harvard.edu |
| Name | Affiliation | Role |
|---|---|---|
| Adam C Jaroszewski, PhD | Harvard Medical School, Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
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|
| Smartphone-delivered inactive Therapeutic Evaluative Conditioning | Behavioral | Therapeutic Evaluative Conditioning (inactive TEC-S) is a behavioral treatment where participants are given optional access to a computerized task/game where they repeatedly pair positive and negative stimuli (pictures, words) with each other. |
|
| Suicide urge (Likert) |
Right now, how strong is your urge to kill yourself [0 (not at all) to 10 (very strong)]; assessed via 3x/day ecological momentary assessment. |
| Through completion of treatment phase (day 1 through 30) |
| Suicide thought incidence | Since the last survey, have you had suicidal thoughts? (yes/no); assessed daily via ecological momentary assessment | Through treatment phase completed (day 1 through 30) |
| Suicide planning incidence | Since the last survey, have you made a plan to kill yourself? (yes/no); assessed daily via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicide preparation incidence | Since the last survey, have you made any preparations to kill yourself? (yes/no); assessed daily via ecological momentary assessment. | Through completion of treatment phase (day 1 through 30) |
| Suicide attempt incidence | Since the last survey, have you attempted to kill yourself? (yes/no); assessed daily via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicidal behaviors (composite) | A composite variable consisting of (i) suicide plan incidence, (ii) suicide preparation incidence, (iii) suicide attempt incidence, each assessed via ecological momentary assessment | Through completion of treatment phase (day 1 through 30) |
| Suicide aversion (AMP) | Suicide aversion assessed implicitly/behaviorally via the Affect Misattribution Procedure (AMP; Payne et al., 2005) | Through completion of treatment phase (day 1 through 30) |
| Suicide aversion (Likert) | Valence ratings of suicide-related pictures using a 9-point scale (-4 [extremely unpleasant] to 0 [neutral] to 4 [extremely pleasant]); assessed weekly (Jaroszewski et al., 2022). | Through completion of treatment phase (day 1 through 30) |
| Self affection (AMP) | Self affection assessed implicitly/behaviorally via the Affect Misattribution Procedure (AMP; Payne et al., 2005) | Through completion of treatment phase (day 1 through 30) |
| ID | Term |
|---|---|
| D059020 | Suicidal Ideation |
| D013406 | Suicide, Attempted |
| D013405 | Suicide |
| ID | Term |
|---|---|
| D016728 | Self-Injurious Behavior |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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