The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis

The Role of Adjuvant Cross Linking in the Management of Infective Keratitis - an OCT Based Assessment Study

This was a prospective, single centre, randomised controlled study to evaluate the clinical effectiveness of corneal collagen crosslinking as an adjuvant to antimicrobial therapy.

This randomised controlled study of forty eyes of forty patients was conducted to assess the impact of corneal collagen crosslinking in addition to antimicrobial therapy.

All forty patients presenting with infective keratitis of various aetiologies (bacterial, fungal, acanthamoeba) were screened and then randomly allocated equally to two groups (A and B). Group A patients were to be offered standard targeted anti-microbial therapy whilst group B were offered CXL in addition to the standard targeted anti-microbial therapy.

Patients were evaluated clinically for visual acuity; infection parameters and dimensions were measured on slit lamp and optical coherence tomography. Evaluations were noted at the baseline visit and subsequently on days 7, 14, and day 30 of treatment

Inclusion Criteria:

• Patients presenting with infectious keratitis

Exclusion Criteria:

• Infective keratitis < 1mm from limbus
• Corneal thickness < 350μm
• Previous herpetic eye disease
• Expectant and nursing women