Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis

Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis

The study is a randomised control trial to assess the visual and clinical outcomes of collagen cross linking in fungal keratitis. Fungal keratitis is a major cause of corneal blindness in India and the therapeutic options available are minimal to handle the advanced complications and sequalae caused by the disease.The antimicrobial and tissue remodeling role of corneal cross linking was demonstrated by several studies earlier,we anted to specifically assess the role of corneal cross linking in non resolving fungal keratitis in prevention of perforation and enhancement of healing process.

Patients with culture positive deep stromal fungal keratitis not responding to appropriate medical therapy for a period of two weeks were randomized to receive or not receive adjuvant CXL. The medical therapy was continued in both the groups and were followed up for 6 weeks after randomization. Healing of the ulcer was taken as successful outcome, while perforation and increase in ulcer size of more than 2 sq.mm from the baseline was considered as treatment failure.

Inclusion Criteria:

• Ulcer size more than 5 mm
• Ulcer depth upto 70% of stromal depth
• Corneal thickness of 400 microns and above

Exclusion Criteria:

• Corneal thickness of below 400 microns
• Ulcers involving the limbus
• Pregnant women
• Children below the age of 18 years