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| Name | Class |
|---|---|
| University of Alberta | OTHER |
| Dalhousie University | OTHER |
| Nova Scotia Health Authority | OTHER |
| University of Toronto |
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EXCEL will provide online and, where feasible, in-person exercise programs to individuals living with and beyond cancer (ILWBC). Research has shown that targeted programs that include tailored exercise prescriptions are more successful in helping individuals with chronic disease to incorporate physical activity and exercise into their daily routines. While ILWBC are advised by healthcare professionals (HCPs) to engage in exercise, there is a lack of cancer-specific exercise programs and cancer-trained exercise specialists in Canada, outside of the research setting. Considering the negative impact cancer and its treatments have on fitness and physical activity levels, community-based efforts towards improving access, uptake and maintenance of exercise programming are needed.
This study will evaluate the benefits of a community-based or online EXCEL exercise program for people living with and beyond cancer across Canada, using a streamlined intake process compared to the original EXCEL Study (HREBA.CC-20-0098, NCT04478851). This 8 to 12-week program (intervention) will be delivered in-person or over virtual platform. It includes twice weekly supervised exercise classes.
Over the past 4.5 years, the EXCEL Study (HREBA.CC-20-0098, NCT04478851) has been implemented across Canada and has recruited over 1500 individuals living with and beyond cancer. This updated study will streamline the program to essential baseline screening and testing (for safe and effective program delivery), simplify outcome assessments (for participants to see changes and for program evaluation), and increase the reach to include more urban centres to encourage more healthcare provider (HCP) buy-in with a simplified referral process (i.e. no patient screening required from HCPs to determine eligibility, based on location). This updated program is based off of the Alberta Cancer Exercise (ACE) Program (HREBA.CC-24-0252). Thus, we are modifying the original EXCEL ethics to will reduce the participant burden with less patient-reported-outcomes and fewer follow-ups, which will allow more focus on program implementation, evaluation, and sustainability. Continued effort and training to establish the clinic-to-community model will be enhanced with stronger relationships and referrals from the cancer care system and the HCPs, which will continue to work towards a 'patient-centered care approach'.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | All participants will be involved in group exercise classes, twice a week for 8-12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group Exercise Classes | Behavioral | Participants will take part in a combination of aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting, twice weekly for a 8-12-week period (duration of intervention depends on scheduling logistics for the coordinating hubs and their spokes sites). The exercise sessions will be conducted in groups with a ratio of up to 15 participants per instructor. The program follows exercise progression principles (i.e., frequency, intensity, time, type, overload and progression) over the 8-12-weeks, with tailoring of any exercise to meet individual participant needs as required, in order to promote fitness and wellness benefits. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Activity Level | The Modified Godin Leisure Time Exercise Questionnaire is used to determine subjective levels of physical activity in each participant. | Baseline to one year |
| Measure | Description | Time Frame |
|---|---|---|
| Cancer related symptoms | Change in Edmonton Symptom Assessment Scale - revised: cancer. Scale is from 0-10, where 0 means the symptom is absent and 10 means the worst possible severity of the symptom is being experienced. | Baseline to one year |
| Cost-effectiveness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julianna Dreger, PhD | Contact | (403) 210-8482 | jdreger@ucalgary.ca | |
| Georgia Kaluznick | Contact | 403-210-8482 | wellnesslab@ucalgary.ca |
| Name | Affiliation | Role |
|---|---|---|
| Nicole Culos-Reed, PhD | University of Calgary | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Calgary | Recruiting | Calgary | Alberta | T2N1N4 | Canada |
No plan at this time to share IPD outside of the research team.
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D011471 | Prostatic Neoplasms |
| D001943 | Breast Neoplasms |
| D003110 | Colonic Neoplasms |
| D008175 | Lung Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D005832 | Genital Diseases, Male |
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| OTHER |
| Centre hospitalier de l'Université de Montréal (CHUM) | OTHER |
| University of British Columbia | OTHER |
| Memorial University of Newfoundland | OTHER |
| University of Prince Edward Island | OTHER |
| Alberta Health services | OTHER |
Hybrid effectiveness-implementation study
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Change in EuroQual - 5Dimensions (EQ-5D) tool - first section is a questionnaire; last section uses a scale from 0-100, where 0 means the worst health imaginable and 100 means the best health imaginable. |
| Baseline to one year |
| Fatigue | Change in Functional Assessment of Chronic Illness Therapy - Fatigue subscale - scale is from 0-4, where 0 means "not at all" and 4 means "very much". | Baseline to one year |
| Quality of life | Single-item measure on quality of life - scale from 0 to 100, where 100 means the best Quality of Life imaginable and 0 means the worst Quality of Life imaginable. | Baseline to one year |
| Body Composition | Change in body mass index (BMI) | Baseline to 12-weeks |
| Aerobic Capactiy | Change in 6-minute walk test (m) or 2 minute step test (steps) results | Baseline to 12-weeks |
| Lower body strength | Change in sit-to-stand (number of repetitions in 30 seconds) | Baseline to 12-weeks |
| Upper extremity flexibility | Change in active shoulder flexion range of motion (degrees) | Baseline to 12-weeks |
| Balance | Change in one legged stance test (seconds) | Baseline to 12-weeks |
| Exercise adherence | Adherence to exercise programming (attendance at sessions) | Duration of the intervention (8-12 week exercise program) |
| Program implementation and evaluation | RE-AIM: program reach, effectiveness, adoption, implementation and maintenance | Baseline to one year |
| University of British Columbia | Recruiting | Vancouver | British Columbia | V6T 1Z7 | Canada |
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| Nova Scotia Health Authority | Recruiting | Halifax | Nova Scotia | B3H 4R2 | Canada |
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| University of Toronto | Recruiting | Toronto | Ontario | M5S 1A1 | Canada |
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| Centre hospitalier de l'Université de Montréal | Recruiting | Montreal | Quebec | H2X 0A9 | Canada |
|
| D000091662 |
| Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D001519 | Behavior |