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| Name | Class |
|---|---|
| University of Alberta | OTHER |
| Dalhousie University | OTHER |
| Alberta Health services | OTHER |
| University Health Network, Toronto |
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Project EXCEL will provide community or online exercise programs to rural and remote and under-served cancer survivors, as well as encourage participants to become life-long exercisers. Exercise is an evidence-based self-management strategy that benefits all cancer survivors. However, most cancer survivors who live in remote or rural places don't have adequate opportunities to be involved in exercise programs that are tailored to their needs.
As cancer survivorship numbers grow, a focus on positive health in survivorship is essential. Exercise is an evidence-based effective self-management strategy that benefits all cancer survivors (CS). However, the majority of research and the limited development of evidence-based clinical or community programs in exercise and cancer has been conducted almost exclusively in urban academic and clinical settings, with very limited implementation outreach to "hard to reach" CS.
In this proposed cancer exercise hybrid implementation effectiveness research, over 5 years we will use an integrated knowledge translation approach to move the current evidence-base that clearly supports the role of exercise in cancer survivorship, into sustainable and effective community-based or online settings that will optimize the delivery of exercise to rural/remote and underserved CS (RCS). Implementing and evaluating the proposed Exercise Oncology Survivorship (EOS) partnership model will result in a sustainable resource to support the implementation and delivery of exercise oncology programs in rural Canadian communities.
Investigators will work to develop lasting referral pathways between cancer care clinics and local fitness professionals. These fitness professionals will have additional cancer specific training to ensure they can effectively and safely deliver the program. Eligible and consenting participants will be screened for exercise safety, and following fitness testing will be triaged to appropriate exercise programming. If, due to COVID-19 public health restrictions, community based programming cannot occur, the exercise sessions will be delivered online by fitness professionals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | All participants will be involved in group exercise classes, twice a week for 12 weeks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group Exercise Classes | Behavioral | The exercise program to be implemented for rural cancer survivors will combine aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting or group personal training format, twice weekly for a 12-week period. If public health restrictions require closure of fitness facilities due to COVID-19, the program will be delivered online. If facilities are open, the sessions will be integrated in the community, delivered in-person. Whether delivered in-class or remotely, the program follows exercise progression principles (ie, frequency, intensity, time, type, overload and progression) over the 12-weeks, with tailoring of any exercise to meet individual participant needs as required, in order to promote fitness and wellness benefits. The exercise intervention is based on the Alberta Cancer Exercise (ACE) program. |
| Measure | Description | Time Frame |
|---|---|---|
| Physical Activity Minutes Per Week | Change in number of participants meeting Guidelines for Physical Activity of 150 minutes per week of moderate intensity exercise, based on accelerometer data from commercially-available activity tracker. | Baseline to one-year |
| Measure | Description | Time Frame |
|---|---|---|
| Body Composition | Change in body mass index (BMI) | Baseline to post 12-week exercise intervention |
| Aerobic Endurance | Change in 6-minute walk test (m) or 2 minute step test (steps) results |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicole Culos-Reed, PhD | Contact | +1 (403) 220-7540 | nculosre@ucalgary.ca | |
| Julianna Dreger, M.ClinExPhys | Contact | +1 (403) 210-8482 | jdreger@ucalgary.ca |
| Name | Affiliation | Role |
|---|---|---|
| Nicole Culos-Reed, PhD | University of Calgary | Principal Investigator |
| Margaret L McNeely, PhD | University of Alberta | Principal Investigator |
| Melanie Keats, PhD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health and Wellness Lab, University of Calgary | Recruiting | Calgary | Alberta | T2N 1N4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36581419 | Derived | Culos-Reed N, Wagoner CW, Dreger J, McNeely ML, Keats M, Santa Mina D, Cuthbert C, Capozzi LC, Francis GJ, Chen G, Ester M, McLaughlin E, Eisele M, Sibley D, Langley J, Chiekwe J, Christensen T; EXCEL Project Team. Implementing an exercise oncology model to reach rural and remote individuals living with and beyond cancer: a hybrid effectiveness-implementation protocol for project EXCEL (EXercise for Cancer to Enhance Living Well). BMJ Open. 2022 Dec 29;12(12):e063953. doi: 10.1136/bmjopen-2022-063953. |
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No plan at this time to share IPD outside of the research team.
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D003110 | Colonic Neoplasms |
| D001943 | Breast Neoplasms |
| D011471 | Prostatic Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
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| OTHER |
| Memorial University of Newfoundland | OTHER |
| University of British Columbia | OTHER |
| University of Prince Edward Island | OTHER |
Hybrid implementation effectiveness study
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| Baseline to post 12-week exercise intervention |
| Upper extremity grip strength | Change in hand-grip dynamometry (kg) | Baseline to post 12-week exercise intervention |
| Functional performance test | Change in sit-to-stand (number of repetitions in 30 seconds) | Baseline to post 12-week exercise intervention |
| Upper extremity flexibility | Change in active shoulder flexion range of motion (degrees) | Baseline to post 12-week exercise intervention |
| Lower extremity flexibility | Change in sit-and-reach test (cm) | Baseline to post 12-week exercise intervention |
| Balance | Change in one legged stance test (seconds) | Baseline to post 12-week exercise intervention |
| Symptom tracking | Change in fatigue, mood, and QOL, recorded via m-Health app | Baseline to one year |
| Cancer related symptoms | Change in Edmonton Symptom Assessment Scale. - scale is from 0-10, where 0 means the symptom is absent and 10 means the worst possible severity of the symptom is being experienced. | Baseline to one year |
| Subjective reporting of average weekly physical activity | Change in Godin Leisure Time Exercise Questionnaire | Baseline to one year |
| General Health-related Quality of Life | Change in EuroQual - 5Dimensions (EQ-5D) tool - first section is a questionniare; last section uses a scale from 0-100, where 0 means the worst health imaginable and 100 means the best health imaginable. | Baseline to one year |
| Fatigue | Change in Functional Assessment of Chronic Illness Therapy - Fatigue subscale - scale is from 0-4, where 0 means "not at all" and 4 means "very much". | Baseline to one year |
| General well-being | Change in Functional Assessment of Cancer Therapy - General subscale - scale is from 0-4, where 0 means "not at all" and 4 means "very much". | Baseline to one year |
| Cognition | Change in Functional Assessment of Cancer Therapy - Cognitive subscale - scale is from 0-4, where 0 means "never" and 4 means "several times a day" (experiencing symptoms). | Baseline to one year |
| Barriers and facilitators to exercise participation | Change in Exercise Barriers and Facilitators questionnaire | Baseline to one year |
| Exercise adherence | Adherence to exercise programming (attendance at sessions) | Baseline to one year |
| Program implementation and evaluation | RE-AIM: program reach, effectiveness, adoption, implementation and maintenance | Baseline to one year |
| Dalhousie University |
| Principal Investigator |
| University of Alberta | Not yet recruiting | Edmonton | Alberta | T6G 2G4 | Canada |
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| Dalhousie University | Not yet recruiting | Halifax | Nova Scotia | B3H 4R2 | Canada |
|
| D004067 |
| Digestive System Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D001519 | Behavior |