Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This randomized controlled trial aims to compare the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) therapy versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the treatment of Post-Traumatic Stress Disorder (PTSD). Adult patients diagnosed with PTSD will be randomly assigned to receive either EMDR therapy or SSRIs for a period of six weeks. The primary outcome is the rate of remission as measured by validated PTSD symptom severity scales at Week 6. Secondary outcomes include changes in functional impairment and patient-reported quality of life. The study seeks to determine whether EMDR therapy is a non-pharmacological alternative to SSRIs for achieving symptom remission in PTSD.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EMDR Therapy | Experimental | Participants will receive Eye Movement Desensitization and Reprocessing (EMDR) therapy over six weeks. |
|
| Selective Serotonin Reuptake Inhibitors (SSRIs)Treatment | Active Comparator | Participants will receive selective serotonin reuptake inhibitors (SSRIs) such as Sertraline over six weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eye Movement Desensitization and Reprocessing Therapy | Behavioral | Patients in this arm will receive weekly EMDR sessions for 6 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Remission rate at Week 6 | Each group's proportion of participants achieving remission from PTSD is defined as having a score below 22 on the PTSD Checklist for DSM-5 (PCL-5; range 0-80, where higher scores indicate worse PTSD symptoms), a validated PTSD scale. | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in functional impairment score | Change from baseline to 6 weeks in functional impairment as measured by the World Health Organization Quality of Life-BREF (WHOQOL-BREF; range 26-130, higher scores = better quality of life), a validated quality of life scale. | 6 weeks |
Not provided
Inclusion Criteria:
Age 18-60 years
Clinical diagnosis of Post-Traumatic Stress Disorder (PTSD)
Duration of illness ≥ 6 months
Able to provide informed consent
Exclusion Criteria:
Current substance abuse or dependence
History of psychotic disorder or bipolar disorder
Active suicidal ideation
Concurrent psychotherapy or psychiatric medication (except study-assigned SSRI)
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Asad Ullah Jan, MBBS,FCPS | CMH Nowshera | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Combined Military Hospital | Nowshera | KPK | 25770 | Pakistan | ||
| Department of Psychiatry, Combined Military Hospital Nowshera |
No plans to share IPD at this time.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Selective serotonin reuptake inhibitors | Drug | The patients will receive an SSRI medication daily for 6 weeks. The dose will be titrated by the clinician. |
|
| Nowshera |
| Kpk |
| 25770 |
| Pakistan |
| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| D003130 | Combat Disorders |
| D014947 | Wounds and Injuries |
| D000092862 | Psychological Well-Being |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
| D010549 | Personal Satisfaction |
| D001519 | Behavior |
Not provided
Not provided
| ID | Term |
|---|---|
| D017367 | Selective Serotonin Reuptake Inhibitors |
| ID | Term |
|---|---|
| D014179 | Neurotransmitter Uptake Inhibitors |
| D049990 | Membrane Transport Modulators |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D018377 | Neurotransmitter Agents |
| D018490 | Serotonin Agents |
| D045505 | Physiological Effects of Drugs |
Not provided
Not provided