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The aim of this study is to assess the potential protective role of selenium on semen parameters and its effect on seminal glutathione peroxidase level in patients on MTX therapy
The aim of this study is to assess the potential protective role of selenium on semen parameters and its effect on seminal glutathione peroxidase level in patients on MTX therapy. informed consent was obtained from each patient after explanation of the purpose of the study. All patients were subjected to history taking and general and local examination. Baseline semen analysis and seminal glutathione peroxidase (GPX) were done for all patients and then they were divided into four groups each has 10 patients.
The no Se or MTX group was not eligible for neither Se nor MTX intake. The Se group started Se intake in a daily dose of 200 µg according to the United States National Academy of Sciences for 3 months.
Patients of both MTX groups (MTX group & MTX and Se group) were chosen from psoriatic patients already planned to start MTX treatment with subcutaneous dose of 0.3-0.4 mg/kg/week.
The MTX and Se group started Se intake in a daily dose of 200 µg according to the United States National Academy of Sciences for 3 months.
After 3 months, semen analysis and seminal GPX level were repeated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No selenium or methotrexate group | No Intervention | no selenium or methotrexate were given | |
| Selenium group | Active Comparator | 200 microgram selenium was given daily for 3 months |
|
| Methotrexate group | Active Comparator | 0.4 mg/kg/week subcutaneous methotrexate was given for 3 months |
|
| Selenium and methotrexate group | Active Comparator | 200 microgram selenium was given daily for 3 months along with 0.4 mg/kg/week subcutaneous methotrexate for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Selenium | Dietary Supplement | 200 microgram selenium was given daily for 3 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glutathione peroxidase level | Seminal glutathione peroxidase level was measured in the four studied groups at baseline and after 3 month duration | from enrollment to 3 months |
| semen volume | Semen volume in (ml) was measured in all patients of the 4 studied groups at baseline and after 3 months | from enrollment to 3 months |
| Sperm count / ejaculate | Sperm count / ejaculate in (million) was measured in all patients of the 4 studied groups at baseline and after 3 months | from enrollment to 3 months |
| Sperm concentration / ml | Sperm concentration / ml in (million) was measured in all patients of the 4 studied groups at baseline and after 3 months | from enrollment to 3 months |
| Sperm motility | percentage of sperm progressive, non progressive and total motility were measured in all patients of the 4 studied groups at baseline and after 3 months | from enrollment to 3 months |
| Sperm morphology | percentage of sperms with normal morphology was measured in all patients of the 4 studied groups at baseline and after 3 months | from enrollment to 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | Abbassia | 00202 | Egypt |
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| ID | Term |
|---|---|
| D012643 | Selenium |
| D008727 | Methotrexate |
| ID | Term |
|---|---|
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008903 | Minerals |
| D000630 |
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| Methotrexate | Drug | 0.4 mg/kg/week sub cutaneous methotrexate for 3 months |
|
| Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |