Evaluate the Efficacy of Selenium for the Prevention of Chemotherapy-induced Mucositis During Autologous Stem Cell Transplantation.

A Randomized Trial to Evaluate the Efficacy of Selenium for the Prevention of Chemotherapy-induced Mucositis During Autologous Stem Cell Transplantation.

Chemotherapy-induced mucositis is an important complication after autologous stem cell transplantation. It is mainly responsible for pain and dysphagia requiring opioids and artificial nutrition. It can also induce infectious complications. A few medication has demonstrated efficacy in this setting. It has been suggested that selenium can reduce the intensity of mucositis due to its antioxydant activity. The investigators therefore perform a randomized study to confirm this preliminary data.

Inclusion Criteria:

• Adult patients receiving autologous stem cell transplantation for lymphoma or myeloma.
• Signed informed consent.

Exclusion Criteria:

• Autologous stem cell transplantation for another medical condition than lymphoma or myéloma.
• Intolerance to selenium.
• High selenium levels before study.
• Pregnancy or patients breast-feeding.