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| Name | Class |
|---|---|
| Chongqing Medical Center for Women and Children | OTHER |
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The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.
hemodynamic significant PDA(hsPDA) is a risk factor for intraventricular hemorrhage(IVH), bronchopulmonary dysplasia(BPD), necrotizing enterocolitis(NEC). A meta-analysis from Cochrane shows that compared to conservative treatment, drug therapy for PDA within 3 and 7 days after birth does not promote PDA closure and reduce the incidence of BPD. Therefore, there is currently a tendency not to provide medication intervention. Although ductus arteriosus quickly closes itself after birth in normal term infants, however, the dynamic changes detail of ductus arteriosus in preterm infants are unknown.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| observation group | in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS) |
| |
| control group | in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observation group | Other | in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of patent ductus arteriosus(PDA) | when did the ductus arteriosus close | three months after birth |
| dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow | dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow were measured | after admission, 12 hour, 24 hour, 48 hour, 72 hour, 96 hour, 120 hour, 144 hour, 168 hour, 192 hour, 216 hour, 240 hour and 2 weeks or any time of ductus arteriosus closed |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of bronchopulmonary dysplasia | whether or not bronchopulmonary dysplasia was assessed in 36 weeks' gestational age | 36 weeks' gestational age |
| the incidence of intraventricular hemorrhage(IVH) |
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Inclusion Criteria:
Exclusion Criteria:
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very preterm infants and extremely preterm infants with respiratory distress syndrome (RDS) and without RDS were included.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Women and Children's hospital of Chonqing Medical University | Chongqing | Chongqing Municipality | 400147 | China |
after paper published
6 months after paper published
Email to neurochenlong@126.com
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| D004374 | Ductus Arteriosus, Patent |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| control group | Other | in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS) |
|
whether or not intraventricular hemorrhage(IVH) was assessed
| 36 weeks' gestational age |
| necrotizing enterocolotis(NEC) | whether or not NEC was assessed | 36 weeks' gestational age |
| D000091642 | Urogenital Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008722 | Methods |