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To define the characteristics of hemodynamically significant PDA by echocardiography, to investigate the systemic effects of the ductus with cerebral and renal Doppler flow studies, and to determine the oxygen consumption in the cerebral tissue with NIRS in newborns below 32 weeks of age with PDA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treated |
| ||
| Untreated |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography, Doppler ultrasonography, Near-infrared spectroscopy | Diagnostic Test | Ecocardiography at 1st, 3rd and 7th day of life Doppler US (cranial and renal) at 1st, 3rd and 7th day of life Near-infrared spectroscopy monitoring after birth during first 3-days of life |
| Measure | Description | Time Frame |
|---|---|---|
| Diameter of PDA | Measurement the diameter of ductus in mm/weight using echocardiography | 1 year |
| Velosity of PDA | Measurement the velosity of ductus using CW doppler on ecocardiyograpy | 1 year |
| Left ventricule expansion | Measurement left ventricule end diastolic and end systolic diameter, left atrium/aort ratio on ecocardiography | 1 year |
| Velocity of internal carotid arteries, middle carotid arteries, anterior cerebral arteries and renal arteries | Measurement velocity of internal carotid arteries, middle carotid arteries, anterior cerebral arteries and renal arteries using doppler ultrasonography | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Newborns < 32 weeks
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Özlem Bayram | Contact | 05058192105 | drbayram.ozlem@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Özlem Bayram | Ankara University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Özlem Bayram | Recruiting | Ankara | 06100 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D004194 | Disease |
| D006330 | Heart Defects, Congenital |
| D004374 | Ductus Arteriosus, Patent |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| D018608 | Ultrasonography, Doppler |
| D019265 | Spectroscopy, Near-Infrared |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |