The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa. In addition, the investigators will learn about the safety of ozonated water and hypochlorous acid solution. The main questions that participants need to answer are:

What medical conditions do participants have while taking ozonated water and hypochlorous acid solution?

Investigators will compare ozonated water and hypochlorous acid solution with 0.12% chlorhexidine gluconate solution to see if it helps to restore the integrity of the oral mucosa.

Participants:

Participants will be asked to agree to receive oral care 4 times a day, every day for 1 week.

Inclusion Criteria:

• Be between the ages of 18-65,
• Have been on mechanical ventilation for at least 24 hours,
• Have no intolerance or allergy to the solutions,
• Agree to participate in the study

Exclusion Criteria:

• Having a contraindication for oral care
• Not agreeing to participate in the study