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68Ga-DOTATATE-based radionuclides are a novel modality in the diagnosis and treatment of central nervous system meningioma. DOTATATE is a ligand for the SSTR (somatostatin receptor), which is expressed in meningioma but not in normal brain or bone. It is also more effective than MRI in delineating tumor, which is the current imaging standard for assessing meningioma. For radiation planning, it can help to reduce the risk of geometrical miss, identify area that require dose-escalation, and reduce dose to normal tissue. The purpose of the study is to compare the radiation therapy (RT) contouring and planning for meningioma with and without the use of 68Ga-DOTATATE-PET
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DOTATATE-PET scan | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DOTATATE-PET scan | Diagnostic Test | DOTATATE tracer PET scan for meningioma |
|
| Measure | Description | Time Frame |
|---|---|---|
| Target radiation volume | The volume of gross total volume (GTV), clinical target volume (CTV), planned target volume (PTV) contours, and volume of dose exposure to normal brain tissue using standard imaging and DOTATE-PET scan | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Local control | 2 years | |
| Progression-free survival | 2 years | |
| Perceived usefulness by radiation oncologist |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sandy Chang | Contact | 6048776000 | sandy.chang@bccancer.bc.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BC Cancer - Vancouver | Vancouver | British Columbia | V5Z 4E6 | Canada |
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| ID | Term |
|---|---|
| D008579 | Meningioma |
| ID | Term |
|---|---|
| D009380 | Neoplasms, Nerve Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009383 | Neoplasms, Vascular Tissue |
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| 2 years |
| Adverse event | 2 years |
| Rate of DOTATATE-scan completion | 2 years |
| Extent of post-operative disease volume compared to MRI | 2 years |
| Overall survival | 2 years |
| D008577 | Meningeal Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009422 | Nervous System Diseases |