Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC

SSTR2-Targeted PET Imaging of Meningioma: Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC

The goal of this study is to propose the first direct comparison of Ga-68-DOTATATE PET/CT or PET/MR and Ga-68-DOTATOC PET/CT in patients with meningioma.

The investigator is proposing a direct comparison of Ga-68-DOTATATE and -DOTATOC in a pilot cohort of patients with meningioma, and hypothesize non-inferiority of DOTATOC. This pilot study will form the basis for a subsequent prospective clinical trial and will allow us to optimize our existing imaging protocols, while developing a more cost-effective protocol.

Primary Objectives:

• Optimize the Ga-68-DOTATOC PET/CT protocol.
• Compare Ga-68-DOTATATE PET and -DOTATOC PET/CT in patients with meningioma.

Secondary Objectives

• Correlate Ga-68-DOTATATE PET and -DOTATOC PET/CT with clinical and pathological characteristics

Inclusion Criteria:

• Adult patients with clinically suspected meningioma
• Patients planned for surgery - undergoing preoperative workup
• No contraindications to either radiotracer

Exclusion Criteria:

• Age less than 18 years
• Inability to lay on the scanner table for the required period of time, e.g., due to bone pain or claustrophobia.