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This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).
In this study, we analyzed the imaging characteristics of HE. First, with the advantages of 7TMRI, we analyzed the differences in imaging characteristics between HE patients and the healthy, including brain functional imaging and structural imaging. Second, we analyzed the differences in imaging characteristics between different subgroups of HE patients. Finally, we analyzed the correlation between the prognostic results of HE patients after follow-up and the imaging characteristics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 7.0T Research | With the advantages of 7.0TMRI, we detect the imaging characteristics of patients with hepatic encephalopathy (HE). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 7.0T MRI-Scan | Other | 7.0T MRI-Scan |
|
| Measure | Description | Time Frame |
|---|---|---|
| Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects. | Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between spectral features of clinical variables and spectral features of imaging. | The clinical variable spectrum characteristics were constructed using the patients' medical records and test data. The distribution characteristics of clinical psychological characteristics and imaging spectrum characteristics were compared using a multidimensional matrix, and gene-imaging association analysis was used to evaluate imaging changes. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with hepatic encephalopathy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jing Tang | Contact | +8618001184224 | jessietang301@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xin Lou | Chinese PLA General Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese PLA General Hospital | Beijing | Beijing Municipality | 100853 | China |
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| ID | Term |
|---|---|
| D006501 | Hepatic Encephalopathy |
| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| 5 years |
| D001928 |
| Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |