7.0T Magnetic Resonance Imaging Study of Parkinson's Disease

7.0T Magnetic Resonance Imaging Study of Parkinson's Disease

This clinical trial study is conducted to detect the imaging characteristics of the patients with Parkinson's diseases (PD) by 7-Tesla (7T) magnetic resonance imaging (MRI).

In this study,we explored the imaging characteristics of PD. First, with the advantage of 7T, we detect the slight changes of PD with short diseases history compared with the healthy. Second, we investigate the different imaging characteristics in subtypes of PD, finding the effective neuroimaging biomarkers to distinguish different subtypes of PD. Finally, we take long time follow-up to evaluate the correlation between the imaging changes and clinical score alteration in PD.

Inclusion Criteria:

• the patients with PD who was diagnosed by the experienced neurologist specializing in movement disorders

Exclusion Criteria:

• the patients with brain disorders such as cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease;
• psychiatric disorders with impaired cognitive function;
• contraindications to MRI.