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| ID | Type | Description | Link |
|---|---|---|---|
| P30AG086635 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are:
Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.
Participants will conduct study activities remotely (e.g., at-home):
During the Baseline Assessment, participants will complete web-based cognitive assessments and surveys. The assessments will address various cognitive functions including working memory, long-term memory, inhibitory control, and sustained attention. Surveys will include a characterization of expectancy for the intervention, ratings of stress, and background health information. The Baseline Assessment will take up to 120 minutes and can be completed across more than one session.
During the Intervention, participants will be provided an iPad tablet to engage with the assigned intervention app. Participants will be randomly assigned to one of two intervention apps. Regardless of the assigned intervention, participants will engage with the app for 25-45 minutes of training per day, 5 days a week for up to 8 weeks for a total of 1000 minutes of training.
After the intervention, participants will complete a Post Intervention Assessment and 6 month later, a Follow-Up Assessment. Both of these assessment periods will consist of the same cognitive assessments and surveys as conducted during the Baseline Assessment.
Upon completion of all study activities, participants will be able to keep the iPad as a gift for their voluntary participation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coherence Intervention | Active Comparator | Participants in this arm will engage with the Coherence Intervention. |
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| Worder Intervention | Active Comparator | Participants in this arm will engage with the Worder intervention. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coherence | Behavioral | Coherence is a music-based rhythm training app. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Working Memory | Working memory performance will be assessed with a delayed match-to-sample task. | Immediately before the intervention, Immediately after the intervention, 6 months after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Inhibitory Control | Inhibitory control will be assessed with the Stroop task. | Immediately before the intervention, Immediately after the intervention, 6 months after the intervention |
| Inhibitory Control |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Melissa Arioli | Contact | (415) 506-7321 | Bid.Core@ucsf.edu |
| Name | Affiliation | Role |
|---|---|---|
| Theodore Zanto, PhD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Francisco | Recruiting | San Francisco | California | 94621 | United States |
De-identified data to be shared includes demographic, cognitive assessments, survey, and behavioral outcomes.
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| Worder |
| Behavioral |
Worder is a word search app. |
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Inhibitory control performance will be assessed by distractors within a delayed match-to-sample task.
| Immediately before the intervention, Immediately after the intervention, 6 months after the intervention |
| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |