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| Name | Class |
|---|---|
| DMT Quest | UNKNOWN |
| ResearchHub | UNKNOWN |
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This study aims to investigate the impact of high ventilation breathwork (HVB) and meditation on altered states of consciousness (ASCs). The study will compare the effects of a single guided HVB session to a single guided body scan meditation session. The primary aim is to explore the impact of HVB and meditation on ASCs, while secondary aims relate to mental health and wellbeing.
The study is a randomised controlled trial (RCT) involving up to 24 healthy adult participants who have prior experience with HVB. Participants will be randomly allocated to either the HVB or meditation group. The study will assess outcomes such as altered states of consciousness, mystical experiences, emotional breakthroughs, and overall wellbeing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meditation | Active Comparator | Single guided body scan meditation session. |
|
| High ventilation breathwork | Experimental | Single guided conscious connected breathing session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High ventilation breathwork | Behavioral | Single guided conscious connected breathing session. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Altered states of consciousness | Five Dimensions of Altered States of Consciousness Scale. Comprises five subscales: oceanic boundlessness, dread of ego dissolution, visionary restructuralisation, auditory alterations and vigilance reduction. Scores range from 0 to 100, with higher scores indicating more profound altered states of consciousness. | Immediately after the intervention. |
| Mystical experience | Mystical Experience Questionnaire Brief. Comprises four subscales: transcendence, positive mood, ineffability, and mystical. Scores range from 0 to 20, with higher scores indicating a more profound mystical experience. | Immediately after the intervention. |
| Emotional breakthrough | Emotional Breakthrough Inventory. Scores range from 0 to 100, with higher scores indicating greater levels of emotional breakthrough (reflecting a better outcome). | Immediately after the intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| Psychological insight | Psychological Insight Scale. Scores range from 0 to 100, with higher scores indicating greater psychological insight. An additional item separately evaluates self-reported behavioural change resulting from a psychedelic experience. | Post-intervention (one week after the intervention). |
| Measure | Description | Time Frame |
|---|---|---|
| Psychedelic experience predictiveness | Imperial Psychedelic Predictor Scale. Scores range from 0 to 100, with higher scores donating higher predictiveness of having a psychedelic experience. Additional items assess rapport. | After completing consent form to participate in the study. |
| General experience |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sussex | Brighton | Sussex | BN1 9RH | United Kingdom |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jun 9, 2025 | Jun 9, 2025 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D019122 | Meditation |
| D051598 | Whole Body Imaging |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026443 | Spiritual Therapies |
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| Meditation | Behavioral | Single guided body scan meditation session. |
|
|
| Depersonalisation |
Cambridge Depersonalisation Scale (State-Version). Scores range from 0 to 100, with higher scores indicating greater levels of dissociative symptoms. |
| Immediately after the intervention. |
| Fatigue | Shortened Fatigue Questionnaire. Scores range from 4 to 28, with higher scores indicating more severe fatigue. | Baseline and post-intervention (one week before and after the intervention). |
| Sleep-related impairment | PROMIS Item Bank v. 1.0 - Sleep-Related Impairment - Short Form 4a (score range: 5-20; higher scores denote worse outcome). Data scored using a T-score transformation according to PROMIS Sleep scoring manual on: www.healthmeasures.net | Baseline and post-intervention (one week before and after the intervention). |
| Mental wellbeing | Short Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS) (score range: 7 to 35; higher scores denote better outcome). Total raw scores are then transformed into metric scores using the SWEMWBS conversion table on: www.warwick.ac.uk | Baseline and post-intervention (one week before and after the intervention). |
| Depressive symptoms, anxiety, and stress | Depression Anxiety Stress Scale-21 (DASS-21) - stress, anxiety and depression subscales (score range for each: 0-21; higher scores denote worse outcomes). Score on DASS-21 then multiplied by two to convert it to the longer form DASS-42 final score. | Baseline and post-intervention (one week before and after the intervention). |
Open-ended, free text. |
| One week post-intervention. |
| D012064 |
| Relaxation Therapy |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |