Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Evaluating the Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines in the Emergency Department

The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

The purpose of this prospective, randomized, double-blinded study is to compare the relative efficacy and safety of intravenous magnesium in conjunction with intravenous prochlorperazine in the treatment of migraines. Participants will be patients presenting to the Emergency Department with primary diagnosis of migraine.

Inclusion Criteria:

• Age ≥ 18 years or older
• Able to provide informed consent
• English speaking
• Primary diagnosis of migraine. Patient with a previous diagnosis of migraine, who experience headaches with typical migraine features (e.g at least 2-3 of the following: recurrent, unilateral, pounding or throbbing in nature, associated with nausea), AND with a clinical exclusion of migraine mimics

Exclusion Criteria:

• Pregnancy defined as a positive urine HCG
• Allergy or sensitivity to study drug
• Stated history of renal insufficiency
• Documented history of myasthenia gravis
• Consumption of study drug within 48 hours prior to enrollment
• Previously enrolled in this trial during a different patient encounter