Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

Migraine is a common disabling neurological condition that significantly affects quality of life. While traditional prophylactic treatments (e.g., beta-blockers, antiepileptics) are effective, they may be associated with side effects leading to poor adherence. Recent evidence suggests that nutraceuticals like magnesium, riboflavin, and coenzyme Q10 may provide a safer alternative. This study aims to compare the efficacy and tolerability of these two approaches.

Primary Objective:

- To compare the reduction in the frequency of migraine attacks between patients receiving conventional prophylactic therapy and those receiving a nutraceutical combination.

Secondary Objectives:

• To evaluate changes in migraine intensity (VAS score), duration, and MIDAS score.
• To assess the side effect profile and patient satisfaction with both interventions.

Inclusion Criteria:

• Adults aged 18-60 years

  • - Diagnosed with episodic migraine (ICHD-3 criteria)
  • - ≥4 migraine attacks/month for the past 3 months
  • - Willing to provide informed consent

Exclusion Criteria:

• • - Chronic migraine (>15 headache days/month)

  • - Use of other prophylactic treatments in past month
  • - History of secondary headaches
  • - Pregnancy or breastfeeding
  • - Significant renal, hepatic, or cardiac disease