Hemodynamic tolerance of fluid removal during deresuscitation is a cornerstone of the impact on outcome of such a strategy. However, how to define and to predict hemodynamic tolerance to fluid removal remains controversial. The investigators routinely use a standardized deresuscitation protocol in patients with fluid overload and continuous renal replacement therapy combined with monitoring of clinical and biological perfusion parameters.

The aim of the study was to describe perfusion during deresuscitation, and to determine whether it is associated with major adverse kidney events at day 30.

Inclusion Criteria:

• Age ≥ 18 years old
• Acute kidney injury requiring continuous renal replacement therapy
• Standardized deresuscitation following a routine care protocol

Exclusion Criteria:

• Chronic hemodialysis
• Advanced directives to withhold or withdraw life-sustaining treatment,
• Patient's opposition to the use of his/her personal health data

adults' patients with fluid overload and continuous renal replacement therapy in intensive care unit