A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)
A Randomized, Open-label, Multicenter, Phase 2 Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)
Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing.
The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.
Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
Trialsites@msd.com1-888-577-8839
Mobile, Alabama 36607, United States
251-435-2273
Burbank, California 91505, United States
Duarte, California 91010, United States
Grand Junction, Colorado 81505, United States
Newark, Delaware 19713, United States
Washington D.C., District of Columbia 20007, United States
Boca Raton, Florida 33486, United States
Miami Beach, Florida 33140, United States
Orange City, Florida 32763, United States
Iowa City, Iowa 52242, United States
Edgewood, Kentucky 41017, United States
Louisville, Kentucky 40207, United States
Baton Rouge, Louisiana 70808, United States
Monroe, Louisiana 71202, United States
Shreveport, Louisiana 71103, United States
Boston, Massachusetts 02215, United States
Burnsville, Minnesota 55337, United States
Morristown, New Jersey 07960, United States
Paramus, New Jersey 07652, United States
Mineola, New York 11501, United States
New York, New York 10016, United States
Chapel Hill, North Carolina 27514, United States
Charlotte, North Carolina 28204, United States
Winston-Salem, North Carolina 27103, United States
Mayfield Heights, Ohio 44124, United States
Portland, Oregon 97225, United States
Philadelphia, Pennsylvania 19104, United States
Sellersville, Pennsylvania 18960, United States
Charleston, South Carolina 29425, United States
Tyler, Texas 75701, United States
Vancouver, Washington 98684, United States
Brussels, Bruxelles-Capitale, Region de 1200, Belgium
Stuttgart, Baden-Wurttemberg 70174, Germany
Frankfurt am Main, Hesse 60389, Germany
Neubrandenburg, Mecklenburg-Vorpommern 17036, Germany
Magdeburg, Saxony-Anhalt 39120, Germany
Lübeck, Schleswig-Holstein 23562, Germany
Meldola, Forli-Cesena 47014, Italy
Alessandria, 15121, Italy
Sendai, Miyagi 983-8520, Japan
Bunkyo, Tokyo 113-8603, Japan
+81-3-3822-2131
Nowy Sącz, Lesser Poland Voivodeship 33-300, Poland
Wałbrzych, Lower Silesian Voivodeship 58-309, Poland
Warsaw, Masovian Voivodeship 02-781, Poland
Gdansk, Pomeranian Voivodeship 80-214, Poland
Bristol, Bristol, City of BS2 8ED, United Kingdom
Plymouth, Devon PL68DH, United Kingdom
Middlesbrough, England TS4 3BW, United Kingdom
London, London, City of SE1 9RT, United Kingdom
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