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The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis of MSA disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MSA-C group | Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-C type (with cerebellar ataxia as the main manifestation) mainly include progressive cerebellar ataxia and autonomic dysfunction. | ||
| MSA-P group | Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-P (multiple system atrophy-P type) mainly include autonomic dysfunction, Parkinson's syndrome and cerebellar ataxia. | ||
| healthy control group | The healthy person who age, gender and other basic conditions matched with the MSA cohort population，and voluntarily participate in this study and sign the informed consent. |
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| Measure | Description | Time Frame |
|---|---|---|
| Standard uptake value ratio(SUVR) | From enrollment to the end of treatment at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| UMSARS | Unified Multiple System Atrophy Rating Scale | From enrollment to the end of treatment at 4 weeks |
| H-Y stage | From enrollment to the end of treatment at 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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People who came to Third Xiangya Hospital of Central South University for consultation or online questionnaire recruitment
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| He RQ 何 | Contact | 0086 186 2214 8869 | hrq1234562001@163.COM |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Third Xiangya Hospital of Central South University | Recruiting | Hunan | Changsha | 410000 | China |
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| ID | Term |
|---|---|
| D019578 | Multiple System Atrophy |
| ID | Term |
|---|---|
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001480 | Basal Ganglia Diseases |
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blood
| SCOPA-AUT | Parkinson's Disease Autonomic Symptoms Scale | From enrollment to the end of treatment at 4 weeks |
| Wexner score | Wexner Continence Grading Scale | From enrollment to the end of treatment at 4 weeks |
| Frontal Assessment Battery | From enrollment to the end of treatment at 4 weeks |
| MoCA score | Montreal Cognitive Assessment | From enrollment to the end of treatment at 4 weeks |
| TSPO Single nucleotide polymorphism genotyping | From enrollment to the end of treatment at 4 weeks |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |