TSPO PET in the Evaluation of Neuroinflammation in Patients with Multiple System Atrophy

TSPO PET in the Evaluation of Neuroinflammation in Patients with Multiple System Atrophy

The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis of MSA disease.

Inclusion Criteria:

• Age> 35 years old, gender is not limited;
• Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
• all patients had been ruled out of polyQ disease by genetic testing;
• Voluntarily participate in this study and sign the informed consent form.

Exclusion Criteria:

• pregnancy or breastfeeding;
• contraindications to MRI examination or inability to cooperate in completing neuroimaging examination;
• previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above);
• History of alcohol or drug abuse