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| Name | Class |
|---|---|
| Jianmin Pharmaceutical Group Co., LTD. | INDUSTRY |
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Central Nervous System (CNS) inflammation is an immune response activated in the brain and spinal cord by microglial cells and astrocytes, commonly occurring under conditions such as central nervous system ischemia, autoimmunity, infection, toxins, and trauma.
Microglial cells, as the innate immune cells of the central nervous system, are responsible for driving the inflammatory response and play a crucial role in sensing environmental changes, responding to harmful stimuli, and engulfing dead neurons. They also present antigens to T lymphocytes, mediating interactions between the peripheral immune system and the central nervous system. Factors released by neuronal cells can either promote or inhibit inflammation, and monitoring the level of inflammation driven by microglial cells is essential for the diagnosis and treatment of central nervous system diseases.
MRI is the primary imaging method for central nervous system inflammation, but it can be challenging to diagnose. PET/MR, a technology that integrates PET and MR imaging, provides high-quality diagnostic images and is valuable for the early detection, diagnosis, and assessment of central nervous system diseases. The radioactive ligand 18F-DPA-714 PET, targeting the translocation protein (TSPO), can visualize activated microglial cells, which may have a gain effect in detecting active central nervous system inflammation.
This study aims to explore the application of 18F-DPA-714 PET/MR in the early diagnosis, treatment evaluation, and prognosis of central nervous system inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICVD | ischemic cerebrovascular diseases |
| |
| Neurological Autoimmune Diseases | Multiple Sclerosis，Neuromyelitis Optica Spectrum Disorders and Autoimmune Encephalitis |
| |
| other | other encephalomyelitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiation: PET-MRI with [18F]-DPA-714 | Radiation | Radiation: PET-MRI with [18F]-DPA-714 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in TSPO Radiotracer Uptake | Quantify the regional neuroinflammatory load, measured as binding of PET tracer to TSPO. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Free Diffusing Water Fraction | Calculated using MR-DWI | 12 months |
| Peripheral Levels of Pro-Inflammatory Cytokines | Evaluated using blood samples, including IL-6, IL-4, IL-10, hs-CRP and PCT etc,al |
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Inclusion Criteria:
-Clinical diagnosis of ischemic stroke, autoimmune ecephalitis, Neuromyelitis optica spectrum disorders, or multiple sclerosis, etc.al
Exclusion Criteria:
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Patients diagnosis with central nervous system diseases (lesions occurring in the brain or spinal cord, such as stroke, autoimmune encephalitis, neuromyelitis optica spectrum disorders, multiple sclerosis, etc.)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luo-qi Zhou, MD | Contact | 86-27-83663337 | zhouluoqi@tjh.tjmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Wei Wang, MD | Tongji Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31296369 | Result | Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke. Lancet Neurol. 2019 Nov;18(11):1058-1066. doi: 10.1016/S1474-4422(19)30078-X. Epub 2019 Jul 8. | |
| 33239064 | Result | Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020 Nov 26;9(1):42. doi: 10.1186/s40035-020-00221-2. |
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| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
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blood, cerebrospinal fluid or feces
| 12 months |
| CSF Levels of Pro-Inflammatory Cytokines | Evaluated using cerebrospinal fluid, IL-6, IL-4, IL-10, hs-CRP and PCT etc, al | 12 months |
| CSF Levels of neural injury markers | Evaluated using cerebrospinal fluid, GFAP, NFL and sTREM2 etc, al | 12 months |
| MRI Correlation | Correlation of white matter lesion volume and MRI measures of white matter tract injury determined from DTI with measures of TSPO uptake | 12 months |
| Inflammatory Markers correlation | Correlation of PET derived measures of TSPO uptake with inflammatory markers (IL-6, IL-4, IL-10, hs-CRP and PCT etc, al) in the blood or cerebrospinal fluid | 12 months |
| Neural injury markers correlation | Correlation of PET derived measures of TSPO uptake with neural injury markers ( GFAP, NFL and sTREM2) in the cerebrospinal fluid | 12 months |
| 30578090 | Result | Voet S, Prinz M, van Loo G. Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology. Trends Mol Med. 2019 Feb;25(2):112-123. doi: 10.1016/j.molmed.2018.11.005. Epub 2018 Dec 18. |
| 33098803 | Result | Kreisl WC, Kim MJ, Coughlin JM, Henter ID, Owen DR, Innis RB. PET imaging of neuroinflammation in neurological disorders. Lancet Neurol. 2020 Nov;19(11):940-950. doi: 10.1016/S1474-4422(20)30346-X. |
| 38441089 | Result | Zhang M, Meng H, Zhou Q, Chunyu H, He L, Meng H, Wang H, Wang Y, Sun C, Xi Y, Hai W, Huang Q, Li B, Chen S. Microglial Activation Imaging Using 18F-DPA-714 PET/MRI for Detecting Autoimmune Encephalitis. Radiology. 2024 Mar;310(3):e230397. doi: 10.1148/radiol.230397. |