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The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High glycemic load | Placebo Comparator |
| |
| Low glycemic load | Experimental |
| |
| Electrical Stimulation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low glycemic load | Other | Low glycemic load diet |
| |
| Electrical stimulation exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Magnitude of systolic blood pressure decrease (in-lab) | Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast and lunch under laboratory-controlled conditions | Visit 2-4, Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Magnitude of systolic blood pressure decrease (at-home) | Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast, lunch, and dinner for 3-days during at-home testing | Visits 2-4, Days 1-3 |
| Postprandial glucose (in-lab) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthew Farrow, PhD | Contact | 614-293-2812 | Matthew.Farrow@osumc.edu | |
| Ceren Yarar-Fisher, PhD | Contact | Ceren.Yarar-Fisher@osumc.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dodd Rehabilitation Hospital | Recruiting | Columbus | Ohio | 43210 | United States |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| Other |
Lower-body electrical stimulation exercise for 1-h after eating |
|
| High glycemic load diet | Other | High glycemic load diet |
|
Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. |
| Visits 2-4, Day 1 |
| Postprandial insulin (in-lab) | Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. | Visits 2-4, Day 1 |
| Postprandial glucose (at-home) | A continuous glucose monitor will be used to measure glucose for 2-h after breakfast, lunch, and dinner for 3-days during at-home testing | Visits 2-4, Day 1-3 |
| Blood flow (in-lab) | Blood flow at the radial, brachial, popliteal and superior mesenteric arteries will be obtained using Doppler imaging at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. | Visits 2-4, Day 1 |
| D014947 | Wounds and Injuries |