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This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Seated control (CON) | Experimental | Participants remain seated in their habitual wheel chair for ~45 min (duration of exercise performed in other arms). Following the intervention they are fed. |
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| Circuit resistance training (CRT) | Experimental | Participants complete upper extremity resistance maneuvers (lifts) interspersed with low-load/high-speed arm cycling for a combined 30 repetitions of 6 lifts and ~20 min of arm cycling. During this time energy expenditure is measured via open-circuit indirect calorimetry. Following the intervention they are fed. |
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| Moderate intensity continuous (MICT) | Experimental | Participants complete continous arm cycling at a steady-state power output (intensity) matched to the energy expenditure (kcal/min) and duration of exercise (min) response during CRT. Following the intervention they are fed. |
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| High intensity interval training (HIIT) | Experimental | Participants complete interval arm cycling at power output that varies between 2 min "active" and two min "recovery" periods. This interval exercise is matched to the total energy expenditure (accumulated kcals) response during CRT. Following the intervention they are fed. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Seated control (CON) | Behavioral | Seated rest |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial insulin sensitivity | Measured by insulin incremental area under the curve (iAUC). | 2.5 hr |
| Postprandial insulin sensitivity | Measured by "ISIMatsuada" insulin sensitivity index. This index is calculated based on the ratio of blood glucose and insulin. | 2.5 hr |
| Measure | Description | Time Frame |
|---|---|---|
| Lipemia | Measured by blood concentrations of triglycerides. | 2.5 hr |
| Carbohydrate use | Whole-body rates of carbohydrate oxidation, as determined by open-circuit indirect calorimetry. |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mark S Nash, Ph.D. | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lois Pope Life Center | Miami | Florida | 33143 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33433151 | Derived | McMillan DW, Maher JL, Jacobs KA, Mendez AJ, Nash MS, Bilzon JLJ. Effects of Exercise Mode on Postprandial Metabolism in Humans with Chronic Paraplegia. Med Sci Sports Exerc. 2021 Jul 1;53(7):1495-1504. doi: 10.1249/MSS.0000000000002593. | |
| 31409383 | Derived | McMillan DW, Maher JL, Jacobs KA, Mendez AJ, Nash MS, Bilzon JLJ. Influence of upper-body continuous, resistance or high-intensity interval training (CRIT) on postprandial responses in persons with spinal cord injury: study protocol for a randomised controlled trial. Trials. 2019 Aug 13;20(1):497. doi: 10.1186/s13063-019-3583-1. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D006949 | Hyperlipidemias |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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Static first arm with randomized remaining three arms.
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| Moderate intensity continuous (MICT) |
| Behavioral |
Arm cycling at a continuous power output |
|
| High intensity interval training (HIIT) | Behavioral | Arm cycling at power outputs that vary between high and low intensity intervals |
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| Circuit resistance training (CRT) | Behavioral | Alternating between six upper extremity resistance maneuvers interspersed with low-resistance/high-speed arm cycling. |
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| Liquid Meal | Other | A liquid meal consisting of 600 kcal comprised of 50% carbohydrate, 35% fat, and 15% protein (by kcal). |
|
| 2.5 hr |
| Fat use | Whole-body rates of fat oxidation, as determined by open-circuit indirect calorimetry. | 2.5 hr |
| Fasted insulin sensitivity | Measured by "HOMA-2" model. This model is calculated based on the ratio of blood glucose and insulin. | Baseline |
| D014947 | Wounds and Injuries |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001519 | Behavior |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |