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This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants. Also aims to determine how vitamin D levels affect these proteins and their role in protecting peri-implant tissues from microbial infections and inflammation.
This cross-sectional clinical study examined 33 patients with 105 dental implants, classified as having either healthy peri-implant tissues or peri-implant diseases. Participants had not received peri-implant treatment in the past six months or taken medications affecting peri-implant tissues in the last three months. Eligible implants had been functional for at least 12 months with prosthetic superstructures that allowed sample collection. Patients with uncontrolled systemic conditions, metabolic bone diseases, autoimmune disorders, or those who were pregnant or breastfeeding were excluded.
Clinical assessments were conducted at six peri-implant sites, measuring probing depth (PD), clinical attachment level (CAL), modified plaque index (mPI), modified sulcus bleeding index (mSBI), and keratinized mucosa width (KMW). Bone loss was evaluated using radiographs. Patients were categorized into three groups based on the 2017 Classification of Periodontal and Peri-implant Diseases: peri-implant health, peri-implant mucositis, and peri-implantitis (35 implants per group).
Peri-implant sulcus fluid (PISF) samples were collected for 25(OH)D and LL-37 analysis using enzyme-linked immunosorbent assay (ELISA). Statistical analysis included normality tests (Kolmogorov-Smirnov), descriptive statistics, one-way ANOVA with Tukey HSD, Kruskal-Wallis with Dunn's test, chi-square tests, and Spearman's correlation for non-normally distributed data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| peri-implant healthy, peri-implant mucositis, peri-implantitis | A total of 105 dental implants from 33 patients were assessed, with 35 categorized in the peri-implant health group, 35 in the peri-implant mucositis group, and 35 in the peri-implantitis group. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay. | Diagnostic Test | In vitro studies have shown that vitamin D promotes the release of antimicrobial peptides from gingival epithelial cells, no clinical research has specifically examined its effect on LL-37 levels in peri-implant tissue diseases. This study seeks to investigate the relationship between vitamin D levels in peri-implant sulcus fluid and clinical parameters in individuals with both peri-implant health and disease. Additionally, it aims to assess the correlation between vitamin D and the antimicrobial peptide LL-37. |
| Measure | Description | Time Frame |
|---|---|---|
| Peri-implant sulcus fluid vitamin D levels and clinical parameters correlation | The association between vitamin D levels in peri-implant sulcus fluid and clinical parameters in individuals with peri-implant health and peri-implant diseases. | At the day of visit (Day 0)- Peri-implant clinical assessments and peri-implant sulcus fluid collection |
| The correlation between vitamin D and the antimicrobial peptide LL-37 | Peri-implant sulcus fluid Vitamin d and LL-37 levels were investigated with ELISA | Laboratory tests were completed after all samples were collected. |
| Mucosal Inflammation | Measurement of mucosal inflammation around implants using modified plaque index (mPI), and modified sulcus bleeding index (mSBI). | At the day of visit (Day 0) |
| Probing Pocket Depth | Measurement of the periodontal pockets depth around implants. Unit of Measure: Millimeters (mm) | At the day of visit (Day 0) |
| Width of Keratinized Mucosa | Measurement of the width of keratinized mucosa around the implants. Unit of Measure: Millimeters (mm) | At the day of visit (Day 0) |
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Inclusion Criteria:
Exclusion Criteria:
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This cross-sectional clinical study included 33 patients with dental implants, exhibiting either healthy peri-implant tissues or peri-implant diseases, who sought treatment at the Department of Periodontology, Faculty of Dentistry, Altınbaş University.
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| Name | Affiliation | Role |
|---|---|---|
| ILKNUR OZENCI, Dr | Altinbas University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Altinbas University | Istanbul | BAKIRKOy | 34147 | Turkey (Türkiye) |
This detailed description provides a comprehensive overview of your study, outlining its objectives, background, methodology, and expected outcomes in a structured and academic manner.
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Peri-implant sulcus fluid
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| ID | Term |
|---|---|
| D057873 | Peri-Implantitis |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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