Vitamin C, also known as ascorbic acid, is a potent reducing agent and antioxidant that plays a crucial role in various metabolic processes.Vitamin B complex, a group of eight essential B vitamins, plays a crucial role in cellular metabolism, energy production, and maintaining nervous system health. There are few available studies on the effects of vitamin B injection on plasma inflammatory markers and its adjuvant analgesic effect along with the routine multimodal analgesia. Considering limited research and existing controversies in this field, the aim of present study is to evaluate the effects of preoperative and intraoperative vitamin B12 administration compared to vitamin C when used as a component of the multimodal analgesic technique in patients undergoing laparoscopic cholecystectomy.

Inclusion Criteria:

• Adult patients (age 18-60 years)
• American Society of Anesthesiologists (ASA) classification I-II
• Patients undergoing laparoscopic cholecystectomy under general anaesthesia

Exclusion Criteria:

• Hypersensitivity to vitamin B complex or vitamin C
• History of chronic pain or use of opioids within the last month
• Patient with inflammatory conditions
• Severe renal or hepatic impairment
• Patient with intellectual disabilities.