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Application of tear ferning test for clinical dry eye diagnosis and menopause
Analyzing the difference in tear ferning structure between women pre and post-menopause with and without hormone replacement therapy (HRT). Tear and blood samples were collected for a menopause-related Enzyme-linked immunosorbent assay. Tear volume, tear osmolarity, intraocular pressure, and tear break-up time were also measured for comparison.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-manepausal women | No Intervention | Collect clinical information, tear and blood samples from women pre-menopause with dry eye syndrome. | |
| Post-manepausal women | Other | Collect clinical information, tear and blood samples from women post-menopause with dry eye syndrome. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pre-manepausal women | Other | Compare tear ferning structure between pre-menopause and post-menopause women. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Schirmer's test | To assess tear secretion volume | 5 minutes |
| Tear film breakup time | To assess tear quality | 20 seconds |
| Ocular surface status | To assess ocular surface health status with lissamine green stain, health or corneal abrasion. | 3 minutes |
| Tear ferning | crystal structure formed from tear drops on a slide be scored. | 30 minutes |
| Menopause related hormone Enzyme-linked immunosorbent assay (ELISA) | To assess FSH/LH/E2/Progesterone/Mc5AC/Lactoferrin concentration between pre- and post-manopause women. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Ocular surface disease index | A questionnaire to assess the health status on ocular surface A final score is calculated which ranges from 0 to 100 with scores 0 to 12 representing normal, 13 to 22 representing mild dry eye disease, 23 to 32 representing moderate dry eye disease, and greater than 33 representing severe dry eye disease. | 20 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David P Lin, PhD | Contact | 886-910-371286 | pcl@csmu.edu.tw | |
| Yiting Tian, Master | Contact | s1000158@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jen-Ai Hospital | Recruiting | Taichung | Taiwan | 412 | Taiwan |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| Intraocular pressure | To determine the effects of intervention on intraocular pressure | 2 minutes |