The Effect of Mannitol Volume With Changes in Osmolarity in Traumatic Brain Injury

The Effect of Mannitol Volume Administration With Changes in Osmolarity in Traumatic Brain Injury: An Observational Study

This observational study is designed to research the effect of mannitol volume administration with changes in osmolarity in patients with traumatic brain injury to guide the safe use of mannitol in these patients.

This prospective observational cohort study included 64 non-operative TBI patients admitted to Dr. Kariadi Central General Hospital, Semarang, Indonesia, between November 2023 and January 2024. Patients received one of three routine clinical regimens: 3×0.25 g/kg, 2×0.5 g/kg, or 3×0.5 g/kg body weight. Mannitol was administered intravenously over 15-20 minutes per dose. Plasma osmolarity was measured at baseline and at 6 and 24 hours following initial administration.

Inclusion Criteria:

• Patients aged 18-40 years
• Glasgow Coma Scale (GCS) score indicating mild (14-13) or moderate (12-10)

Exclusion Criteria:

• Renal impairment
• Multiple trauma with bleeding shock
• Diabetes mellitus