Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring

Compared Effects of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension

Will an increase of the dose of mannitol improve the effects on neuromonitoring in patients suffering intracranial hypertension following traumatic brain injury?

traumatic brain injury intracranial hypertension 0,4 g/ kg vs 0,8 g/ kg (randomized) on 20 minutes monitoring: ICP, transcranial doppler, brain pO2, MAP, HR, diuresis, biology duration: 2 hours

Inclusion Criteria:

• adults
• severe traumatic brain injury
• intracranial hypertension requiring mannitol administration

Exclusion Criteria:

• impeding neurosurgery
• hemodynamic or respiratory severe failure