Incidence, Characterisation and Outcome-relevance of Perioperative SGLT2 Inhibitor Associated Ketoacidosis

Incidence, Characterisation and Outcome-relevance of Perioperative SGLT2 Inhibitor Associated Ketoacidosis - A Multicentre Prospective Cohort Study

The goal of this observational study is to generate data on the incidence and outcome-relevance of sodium-glucose cotransporter 2 (SGLT2) inhibitor associated ketoacidosis in adult patients with regular intake of any SGLT2 inhibitor within the last three months that are undergoing in-patient surgery. Further, it will describe strategies in current clinical practice to prevent and manage SGLT2 inhibitor associated ketoacidosis. The specific aims of this study are:

1. To assess the incidence of SGLT2 inhibitor associated ketoacidosis in surgical patients
2. To characterise fasting times in patients with SGLT2 inhibitor associated ketoacidosis
3. To describe the management of SGLT2 inhibitor associated ketoacidosis in current clinical practice
4. To assess the outcome impact of SGLT2 inhibitor associated ketoacidosis

Inclusion Criteria:

• Prescription and regular intakte of any SGLT2 inhibitor within the last three months (regardless if SGLT2 inhibitor was discontinued preoperatively or not)
• Surgical procedure
• At least one overnight stay in the hospital following surgery
• Age >= 18 years

Exclusion Criteria:

• Unwilling and/or unable to consent
• Outpatient surgery