Treatment With SGLT-2 Inhibitor for Postoperative Hyperglycemia in Acute Abdominal Surgery - a Randomized Trial

Treatment With SGLT-2 Inhibitor for Postoperative Hyperglycemia in Acute Abdominal Surgery - a Randomized Trial

The aim of the study is to investigate the effect of an SGLT-2 inhibitor on postoperative hyperglycemia after acute abdominal surgery in patients without diabetes

Inclusion Criteria:

• - Admitted to the ward after acute abdominal surgery (ASAP patient at Slagelse Hospital, OMEGA patient at Zealand University Hospital)
• At least two independent measurements of blood glucose above 7.7mmol/l within the first 48 hours after surgery
• Age of 18 to 85
• Must be able to understand and sign informed content

Exclusion Criteria:

• Patients diagnosed with diabetes mellitus

  • Impaired kidney function (eGFR < 45mL/min)
  • Severe liver disease (defined as transaminases above X 3 normal levels)
  • Acute pancreatitis within the last two months or a history of chronic pancreatitis
  • Participation in another pharmacological intervention trial
  • Predictable poor compliance (for instance mentally impaired)
  • Pregnancy or lactation (fertile women must have a negative serum or urine pregnancy test to participate)
  • Allergy to study medication