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The objective of this study is to detect the acoustic signals generated by the respiratory system on asthma patients using an acoustic sensor and retrospectively use these signals to identify the characteristics that differentiate patients with asthma and healthy subjects.
The objective of this project is to detect acoustic signals generated by the respiratory system in patients with asthma using the acoustic sensor; and then, retrospectively, to use these signals to carry out signal processing research, with the aim of trying to identify signal characteristics that can be used to differentiate asthma patients from people who do not have the disease.
The hypothesis, therefore, is that it is possible to target through external smart bioelectronic devices and wireless connectivity (wearables) the initial signals of the pathophysiology of bronchial asthma and differentiate them from the signals of the normal respiratory physiology of a healthy individual.
Similarly, detection of such signals would not only be useful for asthma diagnosis but also for monitoring and early detection of exacerbations before they can be detected by the usual respiratory functional tests.
The patients will first visit the asthma unit where the diagnostic tests will be undertaken. Then the subjects will take the acoustic sensor home with them and wear it during sleep for at least two weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Bronchial asthma | Patients with a diagnosis of bronchial asthma, under follow-up by the Asthma Unit. |
| |
| Patients referred for consultation | Patients referred for consultation due to clinical suspicion of bronchial asthma. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spirometry test with bronchodilation | Diagnostic Test | this test measures how much air you can breathe in and out of your lungs, as well as how easily and fast you can then blow the air out of your lungs |
| Measure | Description | Time Frame |
|---|---|---|
| Acoustic respiratory signals | Acoustic signals during the tests performed for asthma diagnosis and while the subjects sleep for at least two weeks. | During the diagnostic tests performed and during the night studies performed by the participant for at least two weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from or referred to the asthma unit in the hospital Virgen del Rocio in Seville, Spain
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Orsina Dessi | Contact | +44 7721877020 | orsina@acurable.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Virgen del Rocio | Seville | Spain |
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| Methacholine challenge | Diagnostic Test | test used to diagnose asthma where the patient breaths in methacholine |
|
| impulse oscillometry | Diagnostic Test | test that uses sound waves to measure how much resistance there is to the normal movement of air in and out of your lungs when you are breathing at rest |
|
| Measurement of the exhaled FeNO fraction | Other | Measure the level of nitric oxide in parts per billion (PPB) in the air the patient slowly exhales |
|
| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D013147 | Spirometry |
| ID | Term |
|---|---|
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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