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| Name | Class |
|---|---|
| National Spasmodic Dysphonia Association | OTHER |
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This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laryngeal Dystonia (LD) tDCS | Experimental | Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Starstim system | Device | Transcranial direct current stimulation (tDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cepstral peak prominence (CPP) | Cepstral peak prominence (CPP) as a robust objective measure of voice quality in the active, sham and no stimulation conditions. | daily on Day 1-Day 5 |
| Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) | Its primary purpose is to describe the severity of auditory-perceptual attributes of a voice problem, in a way that can be communicated among clinicians | daily on Day 1-Day 5 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nabin Koirala, PhD | Contact | 203 7852527 | nabin.koirala@yale.edu |
| Name | Affiliation | Role |
|---|---|---|
| Nabin Koirala, PhD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale University | Recruiting | New Haven | Connecticut | 06511 | United States |
Investigators do not have consent for patients for sharing their data yet, if that changes, de-identified data will be shared.
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| ID | Term |
|---|---|
| D055154 | Dysphonia |
| ID | Term |
|---|---|
| D014832 | Voice Disorders |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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Subjects and staff will be blind during the study and that subjects will be told of their assignment at the follow-up visit.
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| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |