Manual Acupuncture (MA) for Asymptomatic Hyperuricemia (HUA)

Efficacy and Safety Study of Manual Acupuncture (MA) on Serum Uric Acid (SUA) Outcomes in Patients With Asymptomatic Hyperuricemia (HUA): a Multi-center, Randomized, Sham-controlled Trial

Assess the effectiveness of manual acupuncture in modulating serum uric acid levels among patients diagnosed with asymptomatic hyperuricemia.

This is a multicenter randomized, single-blind, sham-controlled trial. A total of 260 eligible patients with asymptomatic hyperuricemia will be randomly assigned in a 1:1 ratio to manual acupuncture group or sham acupuncture group.

Inclusion Criteria:

• With serum uric acid (SUA) level >7 mg/dL after 1 month of a low-purine diet.
• No history of gouty arthritis.
• Has not received uric acid-lowering drug treatment or stopped uric acid- lowering drug treatment ≥ 12 weeks.
• 18.5kg/m2 ≤ body mass index (BMI) ≤ 30.0 kg/m2.
• Can write informed consent.

Exclusion Criteria:

• Patients with poorly controlled hypertension: systolic blood pressure (SBP) ≥ 160mmHg, diastolic blood pressure (DBP) ≥ 100 mmHg.
• Patients with poorly controlled diabetes (hemoglobin A1c ≥ 8.4%).
• Patients with severe liver and kidney damage: chronic kidney disease (CKD) ≥ stage 2 or a serum creatinine, urea, alanine, or aspartate aminotransferase level more than twice of the upper limit.
• Patients with blood system diseases, such as acute and chronic leukemia, polycythemia, multiple myeloma, hemolytic anemia, lymphoma, or undergoing chemotherapy for multiple solid tumors.
• Patients with stroke, coronary heart disease, or severe neuropsychological diseases.
• Patients who are pregnant.
• Illiterate or unwilling to accept acupuncture treatment.