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Renal artery stenosis is a complication that may follow kidney transplantation1-5. Renal artery stenosis greater than 50% of the lumen of the artery, associated with clinical symptoms or laboratory worsening of renal function, may lead to transplant failure, however, the indications for treatment and the modalities of treatment remain, to date, a debated topic in the literature. The guidelines of the European Society of Urology recommend endovascular treatment as the first-line treatment by means of angioplasty and/or stent placement6. A recent review of the literature7 examined the results of 56 studies: the results fully support endovascular treatment of the disease which appears to be effective and with a low rate of complications.
The primary objectives of the study are to evaluate the efficacy (in terms of technical success and graft salvage) and safety (in terms of complications) of endovascular treatment using stenting in patients with renal artery stenosis following kidney transplantation.
Patients undergoing endovascular treatment of renal stenosis following kidney transplantation at the Vascular Surgery Unit from January 2020 to April 2023 (retrospective phase) and from May 2023 up to 2 years from the start of the study.
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| Measure | Description | Time Frame |
|---|---|---|
| Reduction of stenosis | Efficacy is assessed by a reduction in stenosis of at least 50% based on the TC image | From the first patient enrolled up to the 30th patient, an average of 3 years |
| Renal function improvement | It is assessed through the improvement in eGFR and Creatinine values, compared to baseline. | From the first patient enrolled, up to the 30th patient. An average of 3 years |
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Inclusion Criteria:
Exclusion Criteria:
-
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Patients undergoing endovascular treatment of renal stenosis following kidney transplantation at the Vascular Surgery Unit from January 2020 to April 2023 (retrospective phase) and from May 2023 up to 2 years from the start of the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mauro Gargiulo, MD | Contact | 0512143288 | mauro.gargiulo2@unibo.it |
| Name | Affiliation | Role |
|---|---|---|
| Mauro Gargiulo, MD | IRCCS Azienda Ospedaliero-Universitaria di Bologna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS AOU di Bologna Policlinico di Sant'Orsola | Recruiting | Bologna | 40138 | Italy |
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| ID | Term |
|---|---|
| D012078 | Renal Artery Obstruction |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |