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This project will help the patient recover consciousness by giving TI (temporally interfering) treatment
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TI | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| temporally interfering electrical stimulation | Device | temporally interfering electrical stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| CRS-R (Coma Recovery Scale-revised) | The CRS-R scale, with scores ranging from 0 to 23, can help to distinguish unresponsive arousal syndrome from micro-conscious states. | One day before the real/sham stimulus, on the day of the first real/sham stimulus, on the day of the completion of the 10 real/sham stimuli, and 14 days after the completion of the real/sham stimulus |
| Adverse reactions | Any adverse events related to the study | One day before the real/sham stimulus, on the day of the first real/sham stimulus, on the day of the completion of the 10 real/sham stimuli, and 14 days after the completion of the real/sham stimulus |
| Measure | Description | Time Frame |
|---|---|---|
| EEG | phase-locked values, α, β and other EEG power | One day before the real/sham stimulus, on the day of the first real/sham stimulus, on the day of the completion of the 10 real/sham stimuli, and 14 days after the completion of the real/sham stimulus |
| fNIRS（functional near-infrared spectroscopy） |
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Inclusion Criteria:
In accordance with the international diagnostic criteria for MCS formulated by Giacino in 2002 or the diagnostic criteria for UWS proposed by Laureys in 2010; Patients with disease duration ≥28 days and unconscious improvement tendency in the past one month; No use of any sedative drugs or antiepileptic drugs (sodium or calcium channel blockers) in the past 1 month; stable vital signs; No obvious brain edema, hydrocephalus, and severe brain atrophy; Age from 18 to 70 years old; Informed consent was obtained from the patients' family members.
Exclusion Criteria:
Previous history of neurological or psychiatric disorders; Previous history of traumatic brain injury; History of cancer; Taking sedative drugs or antiepileptic drugs in the past 1 month; Unstable vital signs; Skull defect; The patients' family members did not sign the informed consent.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li Zhang | Contact | +86-13732274598 | zhangli0407@zju.edu.cn |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37780965 | Background | Zhu Z, Yin L. A mini-review: recent advancements in temporal interference stimulation in modulating brain function and behavior. Front Hum Neurosci. 2023 Sep 14;17:1266753. doi: 10.3389/fnhum.2023.1266753. eCollection 2023. | |
| 39133053 | Background | Yang C, Xu Y, Feng X, Wang B, Du Y, Wang K, Lu J, Huang L, Qian Z, Wang Z, Chen N, Zhou J, Zhang C, Liu Y. Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease. Mov Disord. 2025 Jun;40(6):1061-1069. doi: 10.1002/mds.29967. Epub 2024 Aug 12. |
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| ID | Term |
|---|---|
| D003244 | Consciousness Disorders |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
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functional connectivity |
| One day before the real/sham stimulus, on the day of the first real/sham stimulus, on the day of the completion of the 10 real/sham stimuli, and 14 days after the completion of the real/sham stimulus |
| GOS-E（Glasgow Outcome Scale - Extended） | The outcome of patients was divided into 8 grades by GOS-E, and the higher the grade, the better the prognosis. | 2 weeks, 1 month, and 3 months after the end of stimulation |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |