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The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcranial Temporal Interference Stimulation | Experimental | tTIS is applied over the bilateral CM-pf for 10 days, once a day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tTIS | Device | CM-pf tTIS |
|
| Measure | Description | Time Frame |
|---|---|---|
| CRS-R total score changes | Coma Recovery Scale-Revised scale score, with score ranging from 0 to 23, was used to evaluate the consciousness condition. | From enrollment to the end of treatment at 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| Numbers of patients with improved consciousness | From enrollment to the end of treatment at 10 days | |
| EEG changes | EEG power spectra, Connectivity and ABCD model, etc | From enrollment to the end of treatment at 10 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gengyao Hu | Contact | 86-15399059833 | 304517021@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| wen Jiang, phD | Xijing Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xijing Hospital | Not yet recruiting | Xi'an | Shaanxi | 710032 | China |
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| Xijing Hospital | Recruiting | Xi'an | Shaanxi | 710032 | China |
|
| ID | Term |
|---|---|
| D003244 | Consciousness Disorders |
| D001930 | Brain Injuries |
| D018458 | Persistent Vegetative State |
| ID | Term |
|---|---|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D001925 | Brain Damage, Chronic |
| D014474 | Unconsciousness |
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