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| ID | Type | Description | Link |
|---|---|---|---|
| 1-16-02-301-24 | Registry Identifier | Internal Registry Central Denmark Region | |
| 2022-0367531 | Registry Identifier | Internal Research Registry Aarhus University |
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The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.
The main questions it aims to answer are:
What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?
Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study cohort | Adult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation. Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positive pressure ventilation during cardiopulmonary resuscitation | Other | The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded. |
| Measure | Description | Time Frame |
|---|---|---|
| Fraction of patients with return of spontaneous circulation (ROSC) | ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes. | ROSC is assessed immediately following cardiopulmonary resuscitation. |
| Measure | Description | Time Frame |
|---|---|---|
| Fraction of patients surviving until day 30 | Patient survival for at least 30 days following cardiac arrest. | Assessed at day 30 after cardiac arrest. |
| Measure | Description | Time Frame |
|---|---|---|
| Fraction of patients with pulmonary complications | Composite endpoint of pulmonary complications after return of spontaneous circulation (ROSC) including acute respiratory distress syndrome (ARDS), aspiration, pneumothorax and hemothorax. | From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days. |
Inclusion Criteria:
Exclusion Criteria:
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Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Johannes Wittig, MD | Contact | +45 78 42 00 00 | johannes.wittig@clin.au.dk | |
| Kasper G Lauridsen, MD, PhD | Contact | +45 78 42 00 00 | kglerup@clin.au.dk |
| Name | Affiliation | Role |
|---|---|---|
| Johannes Wittig, MD | Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark | Principal Investigator |
| Kasper G Lauridsen, MD, PhD | Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark; |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital of Southern Jutland - Aabenraa | Recruiting | Aabenraa | Denmark |
The investigators are not permitted to share IPD.
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| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012151 | Resuscitation |
| D004638 | Emergency Treatment |
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|
| Number of days alive without mechanical ventilation | Days patients are alive without receiving mechanical ventilation after return of spontaneous circulation (ROSC). | From date of ROSC until day 30 or date of death from any cause, whichever came first. |
| Number of days alive outside the intensive care unit | Days patients are alive outside of the intensive care unit after return of spontaneous circulation (ROSC). | From date of ROSC until day 90 or date of death from any cause, whichever came first. |
| Principal Investigator |
| Aalborg University Hospital | Recruiting | Aalborg | 9000 | Denmark |
|
| Aarhus University Hospital | Recruiting | Aarhus | 8200 | Denmark |
|
| Hospital of Southwest Jutland - Esbjerg | Recruiting | Esbjerg | 6700 | Denmark |
|
| Gødstrup Hospital | Recruiting | Gødstrup | 7400 | Denmark |
|
| North Denmark Region Hospital - Hjørring | Recruiting | Hjørring | 9800 | Denmark |
|
| Horsens Regional Hospital | Recruiting | Horsens | 8700 | Denmark |
|
| Odense University Hospital | Recruiting | Odense | 5000 | Denmark |
|
| Randers Regional Hospital | Recruiting | Randers | 8930 | Denmark |
|
| Viborg Regional Hospital | Recruiting | Viborg | 8800 | Denmark |
|
| St. Olavs Hospital, Trondheim University Hospital | Recruiting | Trondheim | 7006 | Norway |
|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012138 |
| Respiratory Therapy |