Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living With Type 1 Diabetes

Effets du Rythme Circadien Sur la régulation glycémique Lors d'Exercices modérés Continus et Intermittents Intenses Chez Des Adolescents Vivant Avec le diabète de Type 1

Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes

Single-center, randomized, controlled study in adolescents living with type 1 diabetes. This study aims to evaluate the effect of exercise timing (morning vs. afternoon) and exercise type (continuous vs. intermittent) on blood glucose levels during and after exercise, as well as to assess the effect of exercise timing (morning vs. afternoon) and type of exercise (continuous vs. intermittent) on blood glucose during and after exercise

Inclusion Criteria:

• Children and adolescents aged 10 to 16;
• Living with type 1 diabetes for at least 1 year with HbA1c less than or equal to 12%;
• Socially insured ;
• Having given their written consent to participate in the research, as well as that of their legal guardians;
• Willing to comply with all research procedures and duration.

Exclusion Criteria:

• Clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate less than 40 ml/min), neuropathy or severe proliferative retinopathy as assessed by the investigator;
• Recent acute macrovascular event (< 3 months), e.g. acute coronary syndrome or cardiac surgery;
• Abnormal blood picture and/or anemia;
• Current pregnancy;
• Other serious medical condition likely to interfere with study participation or ability to complete exercise periods in the judgment of the investigator (e.g., orthopedic limitation);
• Inability to receive informed information;
• Inability to participate in the entire study;
• Lack of social security coverage;
• Refusal to sign the consent form.