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: The objective of this research project will be to determine the sphingolipidomic profile in a group of women (> 18 years) affected by Anorexia Nervosa (AN), phenotypically characterized (restricting [AN-R] vs binge-eating purging [AN-BP]). Specific questionnaires will be administered for the definition of the severity of the eating disorder and depressive state (suicidality), to which will be added the evaluation of gonadal function (i.e., plasma levels of estradiol/progesterone and use of oral contraceptives).
Based on the specific lipidomic profile, which the present research project hopes to characterize, it will be possible to appropriately modify the diet of rehabilitation programs and, in the future, improve the effectiveness of the treatment itself, especially in the long term.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia Nervosa | Adult female Anorexia Nervosa patients, hospitalized at the Division of Eating and Nutrition Disorders (END), Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy |
| |
| Normal weight | Adult normal-weight women with a Body Mass Index between 18.5 and 24.9 kg/m2, recruited from research and hospital staff |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Determination of sphingolipidomic profile | Other | The plasma/serum levels of the following sphingolipids will be measured: ceramides and dihydroceramides from C16 to C24, including 2 unsaturated ones (C18:1 and C24:1), sphingomyelins (those from C16 to C24 and the one C24:1), sphingosine, sphinganine, sphingosine-1-phosphate and sphinganine-1-phosphate. |
| Measure | Description | Time Frame |
|---|---|---|
| Ceramides | Plasma level of ceramide | Baseline |
| Dihydroceramides | Plasma level of dihydroceramides | Baseline |
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Patients with Anorexia Nervosa:
Inclusion Criteria:
Exclusion Criteria:
Control group:
Inclusion Criteria:
Exclusion Criteria:
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30 female adults with Anorexia nervosa, according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), hospitalized at the Division of Eating and Nutrition Disorders (END), San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy.
Half will have the AN-R subtype and the other AN-BP.
30 normal weight adult women recruited from research and hospital staff, with Body Mass Index between 18.5 and 24.9 kg/m2
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alessandro Sartorio, MD | Contact | +390261911 | 2426 | sartorio@auxologico.it |
| Luca Grappiolo, Dr. | Contact | +390261911 | luca.grappiolo@auxologico.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istituto Auxologico Italiano IRCCS, Site Piancavallo | Recruiting | Oggebbio | Verbania | 28824 | Italy |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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Whole blood sample
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