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| Name | Class |
|---|---|
| Institute of Oncology Ljubljana | OTHER |
| Institute of microbiology and immunology, Slovenia | UNKNOWN |
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The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer.
The main questions were:
The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon.
Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with colorectal cancer who recived periodontal treatment | Experimental | Patients with colorectal cancer were treated for periodontal disease based on the condition of their periodontal tissues. |
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| Patients with colorectal cancer who did not recived periodontal treatment | No Intervention | Due to ethical concerns, we selected patients who had completed cancer therapy before the start of our study for the control group, and who met the inclusion criteria based on the completed questionnaires. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| periodontal treatment | Procedure | Based on the results of the dental examination and the diagnosis of the periodontal tissue condition according to the new classification of periodontal disease, we performed appropriate non-surgical treatment of periodontal disease, provided oral hygiene instruction, and took a biofilm sample from the deep periodontal pocket. We then collected a sample of the altered mucosa during bowel surgery for colorectal cancer and conducted a microbiological investigation using quantitative culture to compare the presence of Fusobacterium nucleatum and Porphyromonas gingivalis in the pariodontal pocket and altered intestinal mucosa. |
| Measure | Description | Time Frame |
|---|---|---|
| CRP levels | Measurement of CRP levels in the blood of patients with colorectal cancer at the first examination by the oncological surgeon, on the first and second day after colon resection, and at the first follow-up examination by the oncological surgeon. | From the enrollment to the date of first documented progression at 16 weeks |
| The proportion of Fusobacterium nucleatum and Porphyromonas gingivalis | Using quantitative culture for detection of periodontal bacteria Fusobacterium nucleatum and Porphyromonas gingivalis in the cancer altered intestinal musoca and comparing it with the status in the periodontal pocket | From the first dental exam to the resective colon surgery at 2 weeks |
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Inclusion Criteria:
Additional inclusion Criteria fot the control group:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rok Schara, associate professor, doctor of dental medicine | University Medical Cneter Ljubljana, Division of Stomatology, Center of oral disease and periodontology, | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Ljubljana, Division of stomatology, Center for oral disease and periodontology | Ljubljana | Slovenija | 1000 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40272186 | Derived | Rebersak UP, Brecelj E, Schara R. The influence of periodontal disease and periodontal treatment on colorectal cancer. Radiol Oncol. 2025 Dec 16;59(4):589-596. doi: 10.2478/raon-2025-0025. eCollection 2025 Dec 1. |
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sex, age, clinical diagnosis and location of colorectal cancer, histological diagnosis of the cancer, stage of cancer, BMI, Smoker or not, possible concomitant systemic diseases
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
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| ID | Term |
|---|---|
| D010512 | Periodontal Index |
| ID | Term |
|---|---|
| D003753 | Dental Health Surveys |
| D006306 | Health Surveys |
| D011795 | Surveys and Questionnaires |
| D003625 | Data Collection |
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|
|
| D004067 |
| Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D004812 |
| Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D003813 | Dentistry |
| D010517 | Periodontics |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D011636 | Public Health Dentistry |