Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

Is There a Correlation Between Endometrial CD56 Levels and the Unfavorable KIR AA Genotype in IVF Implantation Success?

This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.

Inclusion Criteria:

• Female patients aged 20-40 years.
• Normal uterine cavity confirmed by hysteroscopy or sonohysterography.
• At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL).

Exclusion Criteria:

• uterine abnormalities,
• systemic autoimmune diseases,
• severe male infertility factors.