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This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| KIR AA (Group A) | In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). A KIR AA haplotype is defined as cen-A and tel-A |
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| KIR non AA (Group B) | In any pregnancy, the maternal KIR genotype could be AA (mostly inhibitory KIRs), AB, or BB (mostly activating KIRs). KIR Bb haplotype is described as cenB/telB, cenA/telB, or cenB/telA |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes | Other | The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts. |
| Measure | Description | Time Frame |
|---|---|---|
| the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success. | The value of CD56 NK cell and KIR AA in patients undergoing IVF and pregnancy rate | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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females undergoing IVF with endometrial biopsy for CD56
A total of 80 patients were included, with 40 in each group (KIR AA and non-KIR AA). All participants provided written informed consent, and the study protocol was approved by the institutional ethics committee.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Calla Ivf Center | Oradea | Bihor County | 410103 | Romania |
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