The aim of this study was to investigate the difference in postoperative pain caused by different root canal sealers in patients with irreversible pulpitis symptoms and no apical lesions.

Inclusion Criteria:

• asymptomatic tooth with delayed positive response to thermal tests and electric pulp tests
• large pulp perforation during caries removal,
• inflamed pulp in which bleeding could not be controlled within 5 min,
• periodontally healthy mature mandibular first or second molar tooth.

Exclusion Criteria:

• patients if they were diabetic, immunocompromised, pregnant,
• had a positive history of antibiotic use during the past 1 month,
• required antibiotic prophylaxis
• used analgesic within 7 days prior to the beginning of treatment,
• were allergic to the materials used during root canal treatment,
• if the bleeding could be controlled within 5 min and vital pulp treatment could be performed,
• the tooth had negative response to vitality tests and/or was symptomatic,
• had an associated periapical lesion visible on a radiograph,
• needed a post-core or was planned to serve as prosthetic support,
• had a calcified root canal and internal or external root resorption,
• had tooth with open apex
• mandibular third molars

Systemically healthy patients between the ages of 18-65