Time Course of Endometrium's Gene Expression Profiles Using Endometrial Tissue and Blood Samples

Time Course of Endometrium's Gene Expression and DNA Methylation Profiles Using Endometrial Tissue and Blood Samples

This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.

Inclusion Criteria:

• Regular menstrual cycle of 28-32 days.
• Between 25-38 years old.
• BMI between 18 to 30.
• Endogenous progesterone (P4) level of < 1 ng/mL prior to exogenous progesterone administration

Exclusion Criteria:

• Suspected intrauterine abnormality.
• Women who are breastfeeding
• Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases.
• History of major illness.
• Use of hormonal contraceptives or intrauterine devices in the past 3 months.