A Comparative Study Between the Efficacy of Diode Laser a... | NCT06782087

Status Module

Record Verification Date

May 2025

Overall Recruitment Status or Expanded Access Status

Enrolling by invitation

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Oct 15, 2025Estimated

Primary Completion Date

Oct 30, 2025Estimated

Completion Date

Oct 30, 2025Estimated

First Submitted Date

Dec 23, 2024

First Submission Date that Met QC Criteria

Jan 13, 2025

First Posted Date

Jan 17, 2025Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Sep 24, 2025

Last Update Posted Date

Sep 25, 2025Actual

Sponsor/Collaborators Module

Responsible Party, by Official Title

Silvia Sabry, lecturer of conservative dentidtry, Misr University for Science and TechnologyPrincipal Investigator

Lead Sponsor

Misr University for Science and TechnologyOTHER

Collaborators

Not provided

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Yes

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Yes

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The growing demand for white smile between patients has increased over recent years, the development of techniques and improvement of materials permits searching for beautiful natural smile.

The discoloration of teeth might be intrinsic, extrinsic, or combined. A variety of commercial bleaching agents is available. The most common substances used are carbamide peroxide or hydrogen peroxide or a mixture of sodium perborate and hydrogen peroxide.

Detailed Description

The aim of the study is to assess the effectiveness of two different in-office bleaching materials carbamide peroxide alone and carbamide peroxide with Chitosan nanoparticles Using diode laser as an activator Regarding tooth whitening and color stability 1 Day , 1 weeks, 1 month after treatment using Vita easy shade.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Phase 1

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

42Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
peroxides and sodium perborate and 980nm diode laser.	Other	peroxides and sodium perborate + 980nm diode laser.	Drug: nano chitosan

Interventions

Name	Type	Description	Arm Group Labels	Other Names
nano chitosan	Drug	nano chitosan	peroxides and sodium perborate and 980nm diode laser.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Color change	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade obtaining difference ∆E* values using colorcoordinates CIE L, a and b*	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade.
color change using digital vita easy shade guide	color change using digital vita easy shade guide	1 day , 1 week , 1 month

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

discolored crown, non-vital or endodontically treated upper central and lateral incisors
previous endodontic treatment performed two or more years earlier.

Exclusion Criteria:

caries on upper central and lateral incisors, inadequate fillings, and progressive periodontal disease.

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

40 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Manal abd el baky A dr, phd	Lecturer in conservative surgery departement	Study Director

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Misr University for science and technology		Giza	Egypt	41211	Egypt

Derived Section

Miscellaneous Info Module

Version Holder

Jul 10, 2026

Removed Countries

Not provided

Submission Tracking

No data available

No data is available for this block.

Condition Browse Module

MeSH Terms

Intervention Browse Module

No data available

No data is available for this block.

ID	Term
D014076	Tooth Diseases
D009057	Stomatognathic Diseases