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The purpose of this study was to conduct a randomized double-blind clinical trial to examine the efficacy of an in-office bleaching regimen with varied activation modes on color stability, surface roughness, tooth sensitivity, and patient satisfaction.
Tooth discoloration is a common esthetic concern that can negatively impact patients' self-confidence and quality of life. Contemporary restorative dentistry increasingly emphasizes minimally invasive approaches, with vital tooth bleaching emerging as a widely accepted, conservative treatment for managing extrinsic and intrinsic discoloration. The effectiveness of bleaching procedures primarily depends on the oxidative degradation of chromogenic compounds within dental hard tissues, leading to improved tooth color.
In-office bleaching techniques often incorporate various activation modes intended to enhance the efficacy of bleaching agents, accelerate treatment time, and improve clinical outcomes. These activation methods may include light-emitting diode (LED) systems, laser activation, or purely chemical activation without external energy sources. Despite their widespread use, the actual benefit of these activation modalities remains controversial, with conflicting evidence regarding their influence on bleaching effectiveness and associated adverse effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laser-Activated In-Office Bleaching | Experimental | Participants receive in-office bleaching using 35% hydrogen peroxide activated by a dental laser system. |
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| Light-Activated In-Office Bleaching | Experimental | Participants receive in-office bleaching using 35% hydrogen peroxide activated by a visible light source |
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| Chemically Activated In-Office Bleaching (Control) | Active Comparator | Participants receive in-office bleaching using 35% hydrogen peroxide without any external activation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) with Laser Activation | Other | Application of a 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) to the labial tooth surfaces, followed by activation using a dental laser according to the manufacturer's recommended parameters. The bleaching procedure is performed in a single clinical session under standardized conditions |
| Measure | Description | Time Frame |
|---|---|---|
| Color Change (ΔE) | Assessment of tooth color change using a digital spectrophotometer (VITA Easyshade® V, Vita Zahnfabrik, Germany). Color measurements will be recorded in the CIE L*a*b* color space, and the overall color difference (ΔE) will be calculated between baseline and subsequent time points. | Baseline (pre-bleaching), immediately post-bleaching, 1 month, and 3 months post-treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Enamel Surface Roughness (Ra, µm) | Evaluation of changes in enamel surface roughness following bleaching procedures. A profilometer used to record average surface roughness (Ra) values in micrometers (µm) | Baseline and immediately after bleaching procedure |
| Tooth Sensitivity |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Restorative Department, Faculty of Dentistry, Tanta University | Tanta | Tanta | 31527 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35976497 | Result | Pereira R, Silveira J, Dias S, Cardoso A, Mata A, Marques D. Bleaching efficacy and quality of life of different bleaching techniques - randomized controlled trial. Clin Oral Investig. 2022 Dec;26(12):7167-7177. doi: 10.1007/s00784-022-04678-5. Epub 2022 Aug 17. | |
| 41340117 | Result | Atay A, Canpolat D, Sismanoglu S, Usumez A. Comparative evaluation of different bleaching agents on the color stability, hardness and surface roughness of indirect esthetic restorative materials with different manufacturing methods. BMC Oral Health. 2025 Dec 4;26(1):36. doi: 10.1186/s12903-025-07355-7. |
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| 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) with LED/Light Activation | Other | Application of a 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) followed by activation using a dental light-curing unit or LED-based bleaching system, according to manufacturer instructions. |
|
| 35% Hydrogen Peroxide Bleaching Gel (Bleach 'n Smile®, Schutz Dental, Germany) - Chemical Activation Only | Other | Application of 35% hydrogen peroxide bleaching agent (Bleach 'n Smile®) without the use of external energy sources, allowing the material to act chemically according to manufacturer instructions. |
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Assessment of patient-reported tooth sensitivity associated with bleaching procedures. Visual Analog Scale (VAS) ranging from 0 (no sensitivity) to 10 (maximum unbearable sensitivity) |
| Immediately after bleaching, 24 hours post-treatment, and up to 7 days post-treatment |
| Patient Satisfaction | Evaluation of patient satisfaction regarding esthetic outcomes and overall treatment experience. Validated questionnaire using a Likert scale (e.g., 1 = very dissatisfied to 5 = very satisfied), covering aspects such as perceived color improvement, comfort, and willingness to undergo the procedure again | Immediately after treatment and at 3-month follow-up |
| 40375839 | Result | Alkhuzaie AI, Elawsya ME, Elkholany NR. Impact of Different Bleaching Methods on Surface Roughness, Microhardness, and Tooth-Restoration Interface of Ormocer- and Methacrylate-based Restorative Systems. J Clin Exp Dent. 2025 Apr 1;17(4):e422-e431. doi: 10.4317/jced.62614. eCollection 2025 Apr. |
| 38303586 | Result | Jiang NW, Cheng YL, Huang HL, Zhong BJ, Bi W, Yu H. Correlation between patient satisfaction and color changes after tooth bleaching. J Esthet Restor Dent. 2024 Mar;36(3):437-444. doi: 10.1111/jerd.13200. Epub 2024 Feb 1. |
| 41387842 | Result | Kurucu Karadeniz BK. Effects of different bleaching methods on the color stability, microhardness, and surface roughness of single-shade composites. BMC Oral Health. 2025 Dec 12;25(1):1895. doi: 10.1186/s12903-025-07147-z. |
| ID | Term |
|---|---|
| D003807 | Dentin Sensitivity |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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