Propolis in Primary Herpetic Gingivostomatitis

Propolis in Management of Primary Herpetic Gingivostomatitis Measuring the Level of INF-γ in Saliva. Randomized Clinical Trial

The purpose of the present study is to investigate the efficacy of 5% propolis gel in the treatment of primary herpetic gingivostomatitis in children and its effect on salivary IFN-γ levels.

Inclusion Criteria:

• clinical manifestations suggestive of PHGS
• positive culture for HSV-1

Exclusion Criteria:

• negative culture for HSV-1
• allergic to honey or its products
• patients diagnosed with any systemic diseases, immunosuppressed or immunocompromised patients