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Haskap berries are rich in cyanidin-3-O-glucoside (C3G), which has been shown in vitro to enhance endothelial function. Previous clinical studies suggest haskap berry supplementation may improve cognition, mood, blood pressure, and athletic performance, but research is limited. This trial aims to contribute to the growing body of evidence on the effects of haskap berry supplementation.
The trial is a 2-period, randomized, double-blinded, cross-over design lasting 16 weeks. During the first period (weeks 0-6), participants will receive either haskap berry powder or a control powder. A 4-week washout period follows (weeks 7-10), where no powder is consumed. In the second period (weeks 11-16), participants will receive the powder they did not consume in the first period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Haskap Powder then Control Powder | Experimental | The participants will consume the haskap powder between weeks 0 and 6. A washout period will occur between weeks 7 and 10. After the washout period, the participants will consume the control powder between weeks 11 and 16. None of the participants or investigators will know the identities of the powder or the participants' allocations. |
|
| Control Powder then Haskap Powder. | Experimental | The participants will consume the control powder between weeks 0 and 6. A washout period will occur between weeks 7 and 10. After the washout period, the participants will consume the haskap powder between weeks 11 and 16. None of the participants or investigators will know the identities of the powder or the participants' allocations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Haskap Berry Powder | Other | The participants will consume four packets (16g) of haskap berry powder. The powder can be consumed with other food products. |
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| Measure | Description | Time Frame |
|---|---|---|
| Systolic Blood Pressure | The participants' mean awake systolic blood pressure will be measured. | Weeks 0, 6, 11, and 16 |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction Time | Mean reaction time to a series of visual stimuli. | Weeks 0, 6, 11, and 16 |
| Memory | Rey Auditory Verbal Learning Test score |
| Measure | Description | Time Frame |
|---|---|---|
| Acceptability | Overall acceptability of the powder via feedback questionnaire | Weeks 6 and 16 |
| Clinical Chemistry | Blood Urea Nitrogen, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, fasting blood glucose, creatinine, creatine, albumin, alanine transaminase, and aspartate amino transferase |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Semone Myrie, PhD | University of Manitoba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Richardson Centre for Food Technology and Research | Winnipeg | Manitoba | R3T 2N2 | Canada |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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The trial will be a 2-period randomized, double-blinded, cross-over study that will last for 16 weeks.
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Neither the participants nor the investigators will know the allocation sequence or the identity of the powders.
| Placebo Powder | Other | The participants will consume four packets (24g) of placebo powder. The powder can be consumed with other food products. |
|
| Weeks 0, 6, 11, and 16 |
| Diastolic Blood Pressure | Mean awake diastolic blood pressure over 3 days | Weeks 0, 6, 11, and 16 |
| Systolic and Diastolic Blood Pressure | Mean systolic and diastolic blood pressure measured over three days. | Weeks 0, 6, 11, and 16. |
| Heart Rate | Mean heart rate measured over three days. | Weeks 0, 6, 11, and 16 |
| Weeks 0, 6, 11, and 16 |
| Weight and waist circumference | Weight (kg) and waist circumference ( inches) will be measured. | Weeks 0, 6, 11, and 16 |
| Nutritional Intake | Total calories, carbohydrates, fat, and protein | Three days before (1) week 0, (2) week 6, (3) week 11, and (4) week 16 |
| Physical Activity | The time spent doing (1) vigorous activities, (2) moderate activities, (3) walking, and (4) sedentary activities. | Weeks 0, 6, 11, and 16 |
| Energy and Mood | Visual analog scale to measure energy and mood | Weeks 0, 6, 11, and 16 |